Buffer BL3

Hazard statements (CLP)

H302, H315

Code

Statements

H302

Harmful if swallowed

2.1 Classification of the substance or mixture

chemical 5.3. Advice for firefighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. precautions for fire-fighters Use personal protection equipment. 6.1. Personal precautions, protective equipment and emergency procedures Personal precautions Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. Use personal protective equipment as required. Avoid breathing vapours or mists. Other information Refer to protective measures listed in Sections 7 and 8. For emergency responders Use personal protection recommended in Section 8. 6.2. Environmental precautions Environmental precautions Prevent further leakage or spillage if safe to do so. 6.3. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal. Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. 6.4. Reference to other sections Reference to other sections See section 8 for more information. See section 13 for more information. 7.1. Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this product. Take off contaminated clothing and wash it before reuse. Avoid breathing vapours or mists. Ensure adequate ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. General hygiene considerations Wear suitable gloves and eye/face protection. Do not eat, drink or smoke when using this product. Avoid contact with skin, eyes or clothing. 7.2. Conditions for safe storage, including any incompatibilities Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach of children. 7.3. Specific end use(s) Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet. 8.1. Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Derived No Effect Level (DNEL) - Workers Chemical name Oral Dermal Inhalation Guanidine hydrochloride 1 mg/kg bw/day [4] [6] 3.5 mg/m3 [4] [6] 50-01-1 10.5 mg/m3 [4] [7] Tris base 166.7 mg/kg bw/day [4] [6] 117.5 mg/m3 [4] [6] 77-86-1 Ethylenediamine tetraacetic acid 1.5 mg/m3 [5] [6] 60-00-4 3 mg/m3 [5] [7] Notes [4] Systemic health effects. [5] Local health effects. [6] Long term. [7] Short term. Derived No Effect Level (DNEL) - General Public Chemical name Oral Dermal Inhalation Guanidine hydrochloride 0.5 mg/kg bw/day [4] [6] 0.87 mg/m3 [4] [6] 50-01-1 Tris base 8.3 mg/kg bw/day [4] [6] 29 mg/m3 [4] [6] 77-86-1 Ethylenediamine tetraacetic acid 25 mg/kg bw/day [4] [6] 0.6 mg/m3 [5] [6] 60-00-4 1.2 mg/m3 [5] [7] Notes [4] Systemic health effects. [5] Local health effects. [6] Long term. [7] Short term. Predicted No Effect Concentration (PNEC) Chemical name Freshwater Marine water Air (intermittent release) Tween 20 0.2 mg/L 0.239 mg/L 0.02 mg/L 9005-64-5 Ethylenediamine 2.2 mg/L 1.2 mg/L 0.22 mg/L tetraacetic acid 60-00-4 Chemical name Freshwater Marine sediment Sewage treatment Soil Food chain sediment Tween 20 1.141 mg/kg 1000 mg/kg 9005-64-5 sediment dw Tris base 300 mg/L 77-86-1 Ethylenediamine 43 mg/L 0.72 mg/kg soil dw tetraacetic acid 60-00-4 8.2. Exposure controls Engineering controls No information available. Personal protective equipment Eye/face protection If splashes are likely to occur, wear safety glasses with side-shields. Hand protection Wear suitable gloves. Impervious gloves. Skin and body protection Wear suitable protective clothing. Long sleeved clothing. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. General hygiene considerations Wear suitable gloves and eye/face protection. Do not eat, drink or smoke when using this product. Avoid contact with skin, eyes or clothing. 9.1. Information on basic physical and chemical properties Physical state Liquid Appearance Liquid Colour clear colourless Odour Odourless. Odour threshold No information available Property Values Remarks • Method Melting point / freezing point No data available None known Initial boiling point and boiling range No data available None known Flammability No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Flash point No data available None known Autoignition temperature No data available None known Decomposition temperature None known pH 7 - 8.5 None known pH (as aqueous solution) No data available None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Water solubility No data available None known Solubility(ies) No data available None known Partition coefficient No data available None known Vapour pressure No data available None known Relative density No data available None known Bulk density No data available Liquid Density No data available Relative vapour density No data available None known Particle characteristics Particle Size No information available Particle Size Distribution No information available Explosive properties No information available Oxidising properties No information available 9.2. Other information 10.1. Reactivity Reactivity No information available. 10.2. Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. 10.3. Possibility of hazardous reactions Possibility of hazardous reactions None under normal processing. 10.4. Conditions to avoid Conditions to avoid Excessive heat. 10.5. Incompatible materials Incompatible materials Strong acids. Strong bases. Strong oxidising agents. 10.6. Hazardous decomposition products Hazardous decomposition products None known based on information supplied. 11.1. Information on toxicological effects Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. May cause irritation of respiratory tract. Harmful by inhalation. (based on components). Eye contact Specific test data for the substance or mixture is not available. Causes serious eye irritation. (based on components). May cause redness, itching, and pain. Skin contact Specific test data for the substance or mixture is not available. Causes skin irritation. (based on components). Ingestion Specific test data for the substance or mixture is not available. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea. Harmful if swallowed. (based on components). Symptoms related to the physical, chemical and toxicological characteristics

UN Number

(SI (SCL) ride 00-0) 2020/1567 50-01-1 as amended) - Acute - Tox. 4 (H302) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319)

Hazard statements

see section 16 This product does not contain candidate substances of very high concern at a concentration >= 0.1% (UK REACH Article 59) 4.1. Description of first aid measures General advice Show this safety data sheet to the doctor in attendance. Inhalation Remove to fresh air. Get medical attention immediately if symptoms occur. If symptoms persist, call a doctor. If breathing has stopped, give artificial respiration. Get medical attention immediately. Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Keep eye wide open while rinsing. Do not rub affected area. Get medical attention if irritation develops and persists. Skin contact Wash off immediately with soap and plenty of water for at least 15 minutes. Get medical attention if irritation develops and persists. Ingestion Do NOT induce vomiting. Rinse mouth. Never give anything by mouth to an unconscious person. Get medical attention. Self-protection of the first aider Avoid contact with skin, eyes or clothing. Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination. Avoid breathing vapours or mists. Use personal protective equipment as required. See section 8 for more information. 4.2. Most important symptoms and effects, both acute and delayed Symptoms May cause redness and tearing of the eyes. Burning sensation. Coughing and/ or wheezing. Difficulty in breathing. Effects of Exposure No information available. 4.3. Indication of any immediate medical attention and special treatment needed Note to doctors Treat symptomatically. 5.1. Extinguishing media Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Special hazards arising from the substance or mixture Specific hazards arising from the No information available chemical Advice for firefighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear precautions for fire-fighters Use personal protection equipment Personal precautions, protective equipment and emergency procedures Personal precautions Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. Use personal protective equipment as required. Avoid breathing vapours or mists Other information Refer to protective measures listed in Sections 7 and 8 For emergency responders Use personal protection recommended in Section 8 Environmental precautions Environmental precautions Prevent further leakage or spillage if safe to do so Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations Reference to other sections Reference to other sections See section 8 for more information. See section 13 for more information Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this product. Take off contaminated clothing and wash it before reuse. Avoid breathing vapours or mists. Ensure adequate ventilation. In case of insufficient ventilation, wear suitable respiratory equipment General hygiene considerations Wear suitable gloves and eye/face protection. Do not eat, drink or smoke when using this product. Avoid contact with skin, eyes or clothing Conditions for safe storage, including any incompatibilities Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach of children Specific end use(s) Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies Derived No Effect Level (DNEL) - Workers Chemical name Oral Dermal Inhalation Guanidine hydrochloride mg/kg bw/day [4] [6] mg/m3 [4] [6] 50-01-1 mg/m3 [4] [7] Tris base 166.7 mg/kg bw/day [4] [6] 117.5 mg/m3 [4] [6] 77-86-1 Ethylenediamine tetraacetic acid mg/m3 [5] [6] 60-00-4 mg/m3 [5] [7] Notes 4] Systemic health effects 5] Local health effects 6] Long term 7] Short term Derived No Effect Level (DNEL) - General Public Chemical name Oral Dermal Inhalation Guanidine hydrochloride mg/kg bw/day [4] [6] 0.87 mg/m3 [4] [6] 50-01-1 Tris base mg/kg bw/day [4] [6] 29 mg/m3 [4] [6] 77-86-1 Ethylenediamine tetraacetic acid 25 mg/kg bw/day [4] [6] mg/m3 [5] [6] 60-00-4 mg/m3 [5] [7] Notes 4] Systemic health effects 5] Local health effects 6] Long term 7] Short term Predicted No Effect Concentration (PNEC) Chemical name Freshwater Marine water Air intermittent release) Tween 20 mg/L 0.239 mg/L 0.02 mg/L 9005-64-5 Ethylenediamine mg/L mg/L 0.22 mg/L tetraacetic acid 60-00-4 Chemical name Freshwater Marine sediment Sewage treatment Soil Food chain sediment Tween 20 1.141 mg/kg 1000 mg/kg 9005-64-5 sediment dw Tris base 300 mg/L 77-86-1 Ethylenediamine 43 mg/L 0.72 mg/kg soil dw tetraacetic acid 60-00-4 Exposure controls Engineering controls No information available Personal protective equipment Eye/face protection If splashes are likely to occur, wear safety glasses with side-shields Hand protection Wear suitable gloves. Impervious gloves Skin and body protection Wear suitable protective clothing. Long sleeved clothing Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required General hygiene considerations Wear suitable gloves and eye/face protection. Do not eat, drink or smoke when using this product. Avoid contact with skin, eyes or clothing Information on basic physical and chemical properties Physical state Liquid Appearance Liquid Colour clear colourless Odour Odourless Odour threshold No information available Property Values Remarks • Method Melting point / freezing point No data available None known Initial boiling point and boiling range No data available None known Flammability No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Flash point No data available None known Autoignition temperature No data available None known Decomposition temperature None known pH 8.5 None known pH (as aqueous solution) No data available None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Water solubility No data available None known Solubility(ies) No data available None known Partition coefficient No data available None known Vapour pressure No data available None known Relative density No data available None known Bulk density No data available Liquid Density No data available Relative vapour density No data available None known Particle characteristics Particle Size No information available Particle Size Distribution No information available Explosive properties No information available Oxidising properties No information available Other information Reactivity Reactivity No information available Chemical stability Stability Stable under normal conditions Explosion data Sensitivity to mechanical impact None Sensitivity to static discharge None Possibility of hazardous reactions Possibility of hazardous reactions None under normal processing Conditions to avoid Conditions to avoid Excessive heat Incompatible materials Incompatible materials Strong acids. Strong bases. Strong oxidising agents Hazardous decomposition products Hazardous decomposition products None known based on information supplied Information on toxicological effects Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. May cause irritation of respiratory tract. Harmful by inhalation. (based on components) Eye contact Specific test data for the substance or mixture is not available. Causes serious eye irritation based on components). May cause redness, itching, and pain Skin contact Specific test data for the substance or mixture is not available. Causes skin irritation. (based on components). Ingestion Specific test data for the substance or mixture is not available. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea. Harmful if swallowed. (based on components). Symptoms related to the physical, chemical and toxicological characteristics Symptoms Redness. May cause redness and tearing of the eyes. Coughing and/ or wheezing. Acute toxicity Harmful if swallowed. Harmful by inhalation. Numerical measures of toxicity The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 621.00 mg/kg ATEmix (dermal) 2,617.10 mg/kg ATEmix (inhalation-gas) 99,999.00 ppm ATEmix (inhalation-vapour) 99,999.00 mg/l ATEmix (inhalation-dust/mist) 1.96 mg/l Unknown acute toxicity 5 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist). Component Information Chemical name Oral LD50 Dermal LD50 Inhalation LC50 Guanidine hydrochloride = 475 mg/kg ( Rat ) > 2000 mg/kg ( Rabbit ) = 3.181 mg/L ( Rat ) 4 h = 7.655 mg/L ( Rat ) 4 h Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation Classification based on data available for ingredients. Causes skin irritation. Serious eye damage/eye irritation Classification based on data available for ingredients. Causes serious eye irritation. Respiratory or skin sensitisation Based on available data, the classification criteria are not met. Germ cell mutagenicity Based on available data, the classification criteria are not met. Carcinogenicity Based on available data, the classification criteria are not met. Reproductive toxicity Based on available data, the classification criteria are not met. STOT - single exposure Based on available data, the classification criteria are not met. STOT - repeated exposure Based on available data, the classification criteria are not met. Aspiration hazard Based on available data, the classification criteria are not met. Other adverse effects No information available. 12.1. Toxicity Ecotoxicity The environmental impact of this product has not been fully investigated. Unknown aquatic toxicity Contains 0 % of components with unknown hazards to the aquatic environment. 12.2. Persistence and degradability Persistence and degradability No information available. 12.3. Bioaccumulative potential Bioaccumulation Component Information Chemical name Partition coefficient Guanidine hydrochloride -1.7 12.4. Mobility in soil Mobility in soil No information available. 12.5. Results of PBT and vPvB assessment PBT and vPvB assessment The product does not contain any substance(s) classified as PBT or vPvB above the threshold of declaration. Chemical name PBT and vPvB assessment Guanidine hydrochloride The substance is not PBT / vPvB 12.6. Other adverse effects No information available. 13.1. Waste treatment methods Waste from residues/unused Dispose of in accordance with local regulations. Dispose of waste in accordance with products environmental legislation. Contaminated packaging Do not reuse empty containers. IATA 14.1 UN number or ID number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing group Not regulated 14.5 Environmental hazards Not applicable 14.6 Special precautions for user Special Provisions None IMDG 14.1 UN number or ID number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing group Not regulated 14.5 Environmental hazards Not applicable 14.6 Special precautions for user Special Provisions None 14.7 Maritime transport in bulk No information available according to IMO instruments RID 14.1 UN number or ID number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing group Not regulated 14.5 Environmental hazards Not applicable 14.6 Special precautions for user Special Provisions None ADR 14.1 UN number or ID number Not regulated 14.2 UN proper shipping name Not regulated 14.3 Transport hazard class(es) Not regulated 14.4 Packing group Not regulated 14.5 Environmental hazards Not applicable 14.6 Special precautions for user Special Provisions None 15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations Authorisations and/or restrictions on use: This product does not contain substances subject to authorisation (UK REACH - Annex XIV). This product does not contain substances subject to restriction (UK REACH - Annex XVII). Persistent Organic Pollutants Not applicable Export Notification requirements Not applicable Named dangerous substances per COMAH (SI 2015/483 as amended) Not applicable The Ozone-Depleting Substances Regulations 2015 Not applicable The Biocidal Products Regulations 2001 (as amended) Not applicable The Water Environment (Water Framework Directive) (England and Wales) Regulations 2017 (as amended) Not applicable Poisons and Explosive Precursors Not applicable International Inventories TSCA Complies DSL/NDSL Complies EINECS/ELINCS Complies ENCS Complies IECSC Complies KECI Complies PICCS Complies AIIC Complies NZIoC Complies Legend: TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AIIC - Australian Inventory of Industrial Chemicals NZIoC - New Zealand Inventory of Chemicals 15.2. Chemical safety assessment Chemical Safety Report No information available Key or legend to abbreviations and acronyms used in the safety data sheet Full text of H-Statements referred to under section 3 H302 - Harmful if swallowed H315 - Causes skin irritation H319 - Causes serious eye irritation Legend SVHC: Substances of Very High Concern for Authorisation