Ceftibuten dihydrate

Health hazards

INFORMATION Usual Adult Dose n/f Adverse Effects Adverse effects of cephalosporins may include nausea; vomiting; taste alteration; decreased salivation; heartburn; decreased appetite; severe abdominal cramps, tenderness, or pain; diarrhea, which may be water, bloody , or severe; fever; unusual bruising or bleeding ; sore mouth or tongue; and anal or genital itching . Drinking alcohol or using alcohol – containing preparations while exposed to this material may cause abdominal cramps, nausea, vomiting, headache, weakness, and flushing. Possible allergic reaction to material if inhaled, ingested or in contact with skin. Overdose Effects n/f Chronic Possible hypersenisitization, superinfections, antibiotic – associated Pseudo membranous colitis.

Medical Conditions Generally Aggravated by Exposure

Hypersensitivity to material, active alcoholism, history of bleeding disorders, concurrent kidney and liver, and gastrointestinal disease, especially ulcerative colitis, regional enteritis, or antibiotic associated colitis. Cross Sensitivity Individual sensitive to penicillins, penicillin derivatives, penicillamine, other cephalosporins , or cephamycin may be sensitive to this material also. Pregnancy Comments Adequate and well-controlled pregnancy studies in humans have not been done, however,animal studies, have not shown that ceftibuten causes adverse effects on the fetus. Overdose Treatment Treatment is symptomatic and supportive and may include 1. For acute hypersensitivity – Administer the usual agents (antihistamines, corticosteroids, or ephineprine, or other pressor amines) , oxygen , and airway management , including intubation. 2. For antibiotic- associated pseudomembranous colitis- Moderate to severe cases may require fluid,electrolyte , and protein replacement . Oral dose of metronidazole, bacitracin, cholestyramine, or vancomycin may be used ; repeat as necessary. Do NOT use antiperistalic antidiarrheals for severe watery diarrhea. 3. Administer anticonvulsants if clinically indicated. 4. Ceftibuten dihydrate is not removed to any significant extent by hemodialysis.