PARTS

SECTION 2: Hazards identification

EMERGENCY OVERVIEW Slight odor. May be fatal if swallowed. Vapors can cause eye irritation. Lowest Known LDS0 (Oral) 107-21-1 5840 mg/kg (Rats) Lowest Known LDSO0 (Skin) 107-21-1 9530 mg/kg (Rabbits) HAZARD RATING SYSTEM NFPA: HEALTH: 1 FLAMMABILITY: 1 REACTIVITY: 0 HMIS: HEALTH: 2 FLAMMABILITY: 1 REACTIVITY: 0 KEY: 0- Minimal 1 - Slight 2 - Moderate 3 - Serious 4 - Severe PARTS MASTER Antifreeze 1

Principle Routes of Exposure

Inhalation, Ingestion, Skin Contact/Absorption, Eye Contact Eye: May cause slight transient (temporary) eye irritation. Corneal injury is unlikely. Vapors or mists may cause eye irritation. Skin: Prolonged or repeated exposure not likely to cause significant skin irritation. A single prolonged exposure is not likely to result in the material being absorbed through skin in harmful amounts. Repeated skin exposure may result in absorption of harmful amounts. Massive contact with damaged skin or of material sufficiently hot to burn skin may result in absorption of potential lethal amounts. Ingestion: Single dose oral toxicity is considered to be moderate. Excessive exposure may cause central nervous system effects, cardiopulmonary effects (metabolic acidosis), and kidney failure. Small amounts swallowed incidental to normal handling operations are not likely to cause injury; however, swallowing amounts larger than that may cause serious injury, even death. Inhalation: At room temperature, exposures to vapors are minimal due to physical properties; higher temperatures may generate vapor levels sufficient to cause adverse effects. Systemic (Other Target Organ) Effects: Repeated excessive exposures may cause severe kidney and also liver and gastrointestinal effects. Signs and symptoms of excessive exposure may be central nervous system effects. Signs and symptoms of excessive exposure may be nausea and/or vomiting. Signs and symptoms of excessive exposure may be anesthetic or narcotic effects. Observations in animals include formation of bladder stones after repeated oral doses of ethylene glycol. Reports of kidney failure and death in burn patients suggest the ethylene glycol may have been a factor. The use of topical applications containing this material may not be appropriate in severely burned patients or individuals with impaired renal function.

Cancer information

Based on data from long-term animal studies, ethylene glycol is not believed to pose a carcinogenic risk to man. Teratology (Birth Defects): Exposure to ethylene glycol has caused birth defects in laboratory animals only at doses toxic to the mother. Reproductive Effects: Ethylene glycol has not interfered with reproduction in animal studies except at very high doses. CHRONIC, PROLONGED OR REPEATED OVEREXPOSURE Effects of Repeated Overexposure: Repeated inhalation of ethylene glycol mist may produce signs of central nervous system involvement, particularly dizziness and nystagmus. Other Effects of Overexposure: repeated skin contact with ethylene glycol may, in a very small proportion of cases, cause sensitization with the development of allergic contact dermatitis. The incidence is significantly less than 1% with the undiluted material. PARTS MASTER Antifreeze 2