Advanced Monomer

SECTION 2: Hazards identification

EMERGENCY OVERVIEW: WARNING: For Mixture: POISON! DANGER! For Ethyl Methacrylate Monomer: Acute Hazards: Eyes: Respiratory Tract: Skin: Digestive Tract: Symptoms: Chronic Hazards: Skin: Animal Studies: For Isopropyl Alcohol: Acute Hazards: Eyes: Ingestion: Inhalation: Skin: Aggravation of Pre-existing Conditions: May be fatal if swallowed. Harmful if inhaled or absorbed through skin. Vapor Harmful. Flammable. Effects Central Nervous System. May cause blindness. Cannot be made not poisonous. Eye contact may cause irritation with discomfort, tearing, or blurring of vision. Inhalation may cause irritation of the respiratory tract with coughing, of nonspecific discomfort, such as nausea, headache and or weakness. Effects in humans include skin irritation with discomfort or allergic skin rashes. Ingestion may cause anesthetic effects such as dizziness, headache, confusion, incoordination, and loss of consciousness May include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. May cause allergic skin rashes. Administered lethal oral doses include weakness, labored and irregular respiration, drop in arterial blood pressure and coma. Vapors cause irritation. Splashes cause severe irritation, possible corneal burns and eye damage. Can cause drowsiness, unconsciousness, and death. Gastrointestinal pain, cramps, nausea, vomiting, and diarrhea may also result. The single lethal dose for a human adult is about 250 milliliters (8 ounces). Vapors irritate the respiratory tract. Exposure to high concentrations has a narcotic effect, producing symptoms of dizziness, drowsiness, headache, staggering, unconsciousness and possibly death. May cause irritation with redness and pain. May be absorbed through the skin with possible systemic effects. Persons with pre-existing skin disorders or impaired liver, kidney or pulmonary function may be more susceptible to the effects of this agent. SECTION 3 - HAZARDS IDENTIFICATION CONTINUED EMERGENCY OVERVIEW CONTINUED: For Dimethacrylate: Acute Hazards: Eyes: Ingestion: Inhalation: Skin: Chronic Hazards: Skin:

Medical Conditions Generally Aggravated by Exposure

For N,N-Dimethyl-p-Toluidine: Acute Hazards: Eyes: Ingestion: Inhalation: Skin Absorption: Chronic Hazards: Suspected irritant. Symptoms may include burning, tearing, redness or swelling. Slight hazard, if ingested in large quantities. Suspected respiratory tract irritant hazard. No significant signs of adverse health hazard due to low volatility of material. However, aerosols or vapors which are generated at elevated temperatures may cause irritation. Symptoms may include coughing, mucous production and shortness of breath. Moderate irritant/allergic sensitizer. Extensive/prolonged or repeated exposure can result in significant absorption. A major component in this product has been shown to produce allergic skin sensitization in guinea pigs. Cross-sensitization reactions to similar materials have also been reported in this species. Dermatitis has been seen in animal studies. This material or its emissions may induce allergic or sensitization reaction and thereby aggravate systemic disease. May cause irritation. May cause methemoglobinemia. Causes elevated methemoglobin in the blood. Symptoms may include headaches, weakness and dizziness, and can be recognized by the blue color of the lips, fingernails, nose and earlobes. Vapor or mist is irritating to mucous membranes and upper respiratory tract. Liquid is rapidly absorbed through skin. Absorption of this product into the body causes the formation of methemoglobin, which in sufficient concentration causes cyanosis, symptoms include headache, dizziness, nausea and abdominal pain. In case of blue discoloration (cyanosis) of skin, lips or fingernails give oxygen to breathe. No alcohol or physical exertion. Contact a physician. Existing cardiovascular or respiratory conditions, blood disorders and dermatitis. SECTION 3 - HAZARDS IDENTIFICATION CONTINUED EMERGENCY OVERVIEW CONTINUED: For N,N-Dimethyl-p-Toluidine continued: Note to Physicians: For p-Hydroxyanisole: Acute Hazards: Eyes: Ingestion: Inhalation: Skin: Duration: Chronic Hazards: Eyes: Skin: CARCINOGENICITY:

Principle Routes of Exposure

Absorption of this product leads to formation of methemoglobin, which in sufficient concentration causes cyanosis. Reversion of methemoglobin to hemoglobin occurs spontaneously after termination of exposure, moderate degree of cyanosis need to be treated only by supportive measures such as bed rest and oxygen inhalation. Thorough cleansing of the entire contaminated area is of utmost importance. If cyanosis is severe, intravenous injection of methylene blue, 1-2 mg/kg body weight over a 5 minute period as a 1 % solution may be of value. If elevated methemoglobin persists after an hour, the treatment may be repeated, but the total dose should not exceed 7 mg/kg body weight. Cyanocobalmin (Vitamin B-12), 1 mg intramuscularly is reported to speed recovery. Intravenous fluids and blood transfusions may be indicated in very severe exposures. Risk of serious damage. Harmful if swallowed. Harmful if inhaled, irritating to mucous membranes and upper respiratory tract. Harmful if absorbed through skin. Depending on the intensity and duration of exposure, effects may vary from mild irritation to severe destruction of tissue. Prolong contact may cause eye damage. May cause severe burns or irritation. Isopropyl Alcohol is not classifiable as a human carcinogen by IARC. The Dimethacrylate may contain trace quantities of substances known to the state of California to cause cancer and/or reproductive toxicity. All other components are not listed as carcinogens by ACGIH, IRAC or NTP. Ingestion, Inhalation, Eyes or Skin.