Methylene Chloride, Technical Grade

SECTION 2: Hazards identification

GHS Classification _________________________________________________________________________________________________ OSHA REGULATORY STATUS: This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). ******************************************************************************************************************************** EMERGENCY OVERVIEW: Color: Colorless Physical State: Liquid

Appearance/Odor

Clear Chloroform-like odor

Signal word

DANGER DANGER

Health hazards

HARMFUL IF SWALLOWED. MAY BE HARMFUL IF SWALLOWED AND ENTERS AIRWAYS. CAUSES SKIN IRRITATION. CAUSES SERIOUS EYE IRRITATION. MAY CAUSE DROWSINESS OR DIZZINESS. SUSPECTED OF CAUSING GENETIC DEFECTS. MAY CAUSE CANCER. CAUSES DAMAGE TO CARDIOVASCULAR SYSTEM INCLUDING ELEVATED CARBOXYHEMOGLOBIN LEVELS. MAY CAUSE DAMAGE TO LIVER THROUGH PROLONGED OR REPEATED EXPOSURE.

Precautionary statements

Obtain, read, and follow all safety instructions before use. Do not breathe mist, vapors, or spray. Wash hands and exposed skin and clothing thoroughly after handling. Do not touch eyes. Do not eat, drink, or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves, protective clothing, eye, and face protection. - Prevention • Obtain, read, and follow all safety instructions before use • Do not breathe mist, vapors, or spray • Wash hands and exposed skin and clothing thoroughly after handling. Do not touch eyes • Do not eat, drink or smoke when using this product • Use only outdoors or in a well-ventilated area • Wear protective gloves/protective clothing/eye protection/face protection/hearing protection - Response • IF SWALLOWED: Get emergency medical help immediately • Rinse mouth • IF ON SKIN: Wash with plenty of soap and water • If skin irritation occurs: Get medical help • Take off contaminated clothing and wash it before reuse • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing • If eye irritation persists: Get medical help • IF INHALED: Remove person to fresh air and keep comfortable for breathing • IF INHALED: Get medical help if you feel unwell • IF exposed or concerned: Get emergency medical help immediately • Specific treatment (see "Notes to Physician" in Section 4 of the SDS) - Storage • Store in a well-ventilated place. Keep container tightly closed • Store locked up - Disposal • Dispose of contents and container in accordance with applicable local, regional, national, and/or international regulations Health Hazards of Significance Not Mentioned in GHS Classification • Methylene chloride can be metabolized to carbon monoxide (CO), which is then very tightly bound to hemoglobin. This complex is called carboxyhemoglobin (COHb) and results in a reduction in the oxygen carrying capacity of the blood • Exposure in an enclosed or poorly ventilated area may be very harmful • May cross the placenta. May be excreted in breast milk; however, there were no indications of neonatal toxicity due to exposure of the parenteral group to Methylene Chloride during gestation and lactation. • This material may be absorbed across the skin causing systemic effects

Additional information

Exposure in an enclosed or poorly ventilated area may be very harmful Methylene chloride can be metabolized to carbon monoxide (CO), which is then very tightly bound to hemoglobin. This complex is called carboxyhemoglobin (COHb) and results in a reduction in the oxygen carrying capacity of the blood. This product may be absorbed through the skin, causing systemic effects. ******************************************************************************************************************************** Methylene chloride is listed on The Endocrine Disruptors Exchange's (TEDX) List of Potential Endocrine Disruptors (ED) database of chemicals with the potential to affect the endocrine system. Every chemical on the TEDX List has one or more verified citations published, accessible, primary scientific research demonstrating effects on the endocrine system. Literature data concerning reproductive/developmental effects points out directly to a potential ED-like mode of action. In particular, taking into account both: i) the CYP-mediated mechanism(s) supporting both hepatic and biliary tract carcinogenesis alert at low dichloromethane doses, and ii) the CYP2E1-mediated mechanism supporting the reproductive/developmental alert in the male germ line, a concern on the possibility that dichloromethane could act via an ED-like mechanism exists. A study (Mennear JH et al., 1988) on dichloromethane-mediated carcinogenesis in F344/N rats indicated that a set of endocrine-regulated tissues (mammary glands, testis, adrenals) were responding, in a non-linear dose-dependent manner, to the treatment with dichloromethane, suggesting a possible relationship with disturbed endocrine function and raising the possibility of a hormonal-mediated mechanism(s) at a realistic scenario of exposure to humans. See Section 11: TOXICOLOGICAL INFORMATION _________________________________________________________________________________________________

2.1 Classification of the substance or mixture

GHS: CONTACT HAZARD - SKIN: Category 2 - Causes skin irritation GHS: CONTACT HAZARD - EYE: Category 2A - Causes serious eye irritation GHS: ACUTE TOXICITY - ORAL: Category 4 - Harmful if swallowed GHS: TARGET ORGAN TOXICITY (SINGLE - Category 1 - Causes damage to cardiovascular system EXPOSURE): including elevated carboxyhemoglobin levels - Category 3 - May cause drowsiness or dizziness GHS: TARGET ORGAN TOXICITY (REPEATED Category 2 - May cause damage to liver through EXPOSURE): prolonged or repeated exposure GHS: CARCINOGENICITY: Category 1B - May cause cancer GHS: GERM CELL MUTAGENICITY: Category 2 - Suspected of causing genetic defects

Aspiration hazard

CATEGORY 2 May be harmful if swallowed and enters airways - CATEGORY 2 May be harmful if swallowed and enters airways

Hazard pictograms

Exclamation mark, Health hazard

Hazard statements

GHS - Health Hazard Statement(s) • Harmful if swallowed • Causes skin irritation • Causes serious eye irritation • May cause drowsiness or dizziness • Suspected of causing genetic defects • May cause cancer • Causes damage to cardiovascular system including elevated carboxyhemoglobin levels • May cause damage to Liver through prolonged or repeated exposure Additional Hazards - GHS Hazards Not Otherwise Classified (HNOC):