R-2183 PART A

SECTION 2: Hazards identification

EFFECTS OF SINGLE OVEREXPOSURE: SWALLOWING: Slightly toxic. May cause nausea, vomiting and diarrhea. Swallowing of large quantity may lead to central nervous system disturbances, such as convulsions, depression, or coma. Aspiration into the lungs may occur during ingestion or vomiting, resulting in lung injury. SKIN ABSORPTION: No evidence of adverse effects from available information. INHALATION: Vapor may be irritating, experienced as nasal discomfort and discharge, with dizziness, headache, giddiness, and unconsciousness. Severe overexposure by inhalation may result in permanent lung damage. SKIN CONTACT: Brief contact is not irritating. Prolonged contact, as from clothing wet with the material, may cause moderate irritation seen as local redness. EYE CONTACT: Liquid causes irritation, experienced as stinging, excess blinking and tear production, with excess redness and swelling of the conjunctiva. High vapor concentrations cause tearing and irritation. EFFECTS OF REPEATED OVEREXPOSURE: Ethylbenzene – prolonged and repeated exposure may be harmful to the central nervous system (CNS), upper respiratory tract, and/or may cause liver disorders. It may also cause drying, scaling, and blistering of the skin. Ethylbenzene has been classified by IARC as Group 2B (possibly carcinogenic to humans) based on the NATIONAL Toxicology Program’s two year study of very high exposure levels on rats and mice (NTP, 1999). Rats and micewere exposed to concentrations of 0, 250, or 750 ppm of Ethylbenzene for 6 hours per ay per week for 104 and 103 weeks, respectively. There were statistically significant increases in the incidence of kidney tumors in males and female rats, lung tumors in malesmice, and liver tumors in female mice exposed to 750 ppm of Ethylbenzene. The relevance of these data to human exposure is presently being evaluated. The International Agency for Research on Cancer (IARC) has classified ethyl benzene as a possible human carcinogen. No injury from silica dust should occur during reasonable use. If use creates respirable particles, some respiratory system injury may occur. However, since the silica in this product is compounded into the polymer matrix, it is not expected to present the same hazards as in its neat form.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE Because of its irritating and defatting properties, this material may aggravate an existing dermatitis. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: This material (or a component) may be harmful to the human fetus based on positive test results with laboratory animals. This material (or component) has been shown to cause birth defects in laboratory animals studies. Toluene may be harmful to the human fetus based on positive test results with laboratory animals. Case studies show that prolonged intentional abuse of toluene during pregnancy can cause birth defects in humans. OTHER EFFECTS OF OVEREXPOSURE: None currently known.