MED-6607

SECTION 2: Hazards identification

EFFECTS OF SINGLE OVEREXPOSURE: SWALLOWING: This product may be harmful or fatal if swallowed. This product may cause nausea, vomiting, diarrhea and restlessness. DO NOT INDUCE VOMITING. Aspiration into the lungs can cause severe chemical pneumonitis or pulmonary edema/hemorrhage, which can be fatal. May cause gastrointestinal disturbances. Symptoms may include irritation, depression, vomiting and diarrhea. May cause harmful central nervous system effects, similar to those listed under “INHALATION”. SKIN ABSORPTION: Can be absorbed through skin. INHALATION: Nasal and respiratory tract irritation, central nervous system effects including excitation, euphoria, contracted eye pupils, dizziness, drowsiness, blurred vision, fatigue, nausea, headache, loss of reflexes, tremors, convulsions, seizures, loss of consciousness, coma, respiratory arrest and sudden death could occur as a result of long term and/or high concentration exposure to vapors. May also cause anemia and irregular heart rhythm. Repeated or prolonged exposure may cause behavioral changes. SKIN CONTACT: Prolonged or repeated contact may cause moderate irritation, defatting (cracking), redness, itching, inflammation, dermatitis and possible secondary infection. High pressure skin injections are SERIOUS MEDICAL EMERGENCIES. Injury may not appear serious at first. Within a few hours, tissues will become swollen, discolored and extremely painful. See “NOTES TO PHYSICIAN”. EYE CONTACT: May cause irritation, redness, tearing, blurred vision and conjunctivitis. EFFECTS OF REPEATED OVEREXPOSURE: Inhalation over a prolonged period will produce symptoms of dizziness, weakness, pain in the limbs, paresthesias, and nervousness, and lead to anemia and weight loss. No injury from silica or other dust should occur during reasonable use. If use creates respirable particles, then some respiratory system injury may occur. However, since the silica in this product is compounded into the polymer matrix, it is not expected to present the same health hazard as neat silica.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE Preexisting eye, skin, heart, central nervous system and respiratory disorders may be aggravated by exposure to this product. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: Prolonged and repeated inhalation exposure to hydrocarbon vapor in the same boiling range has produced kidney damage in male rats. This effect has not been observed in female rats and male and female mice. The relevance of this information to humans is unknown. VM&P Naphtha can affect the body if it is inhaled, comes in contact with the eyes or skin or is swallowed. The vapors of petroleum distillates are mild narcotics and mucous membrane irritants. Human subjects had upper respiratory tract irritation in 15 minutes at 880 ppm. Eye irritation and transient olfactory fatigue also occurred. VM&P Naphtha is reported to have an acute toxicity greater than rubber solvent. In a subchronic oral toxicity animal study, methyl ethyl ketoxime (MEKO), which is given off during cure, produced an adverse effect upon red blood cells (anemia). This was found for all dose levels tested. In an acute dermal animal study, 200 mg/kg caused mild hematologic (blood) effects. No effects were seen at 20 mg/kg. Liver carcinomas were observed in a lifetime inhalation study in which mice and rats were exposed to MEKO 6 hrs/day, 5 days/week for 18 months and 26 months, respectively. These carcinomas were statistically increased in males at a MEKO concentration of 375 ppm. In addition, degenerative effects on the olfactory epithelium of the nasal passages occurred in a concentration related manner in males and females of both species at MEKO concentrations of 15, 75, and 375 ppm. The relevance of this data to human health is unknown. OTHER EFFECTS OF OVEREXPOSURE: None known.