CV9-1142

SECTION 2: Hazards identification

EFFECTS OF SINGLE OVEREXPOSURE: SWALLOWING: May cause nausea, vomiting. SKIN ABSORPTION: No evidence of adverse effects from available information. INHALATION: High concentrations of vapor may cause irritation, experienced as nasal discomfort and discharge, with chest pain and coughing. SKIN CONTACT: May cause slight irritation with slight discomfort, seen as mild local redness. EYE CONTACT: Causes irritation, experienced as discomfort, with excess blinking and tear production, and seen as excess redness and swelling of the conjunctiva. EFFECTS OF REPEATED OVEREXPOSURE: No injury from silica or dust should occur during reasonable use. If use creates respirable particles, some respiratory system injury may occur. However, since the silica in this product is compounded into the polymer matrix, it is not expected to present the same hazard as neat silica.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE A knowledge of the available toxicology information and of the physical and chemical properties of the material suggests that overexposure is unlikely to aggravate existing medical conditions. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: In a subchronic oral toxicity animal study, methyl ethyl ketoxime (MEKO), which is given off during cure, produced an adverse effect upon red blood cells (anemia). This was found for all dose levels tested. In an acute dermal animal study, 200 mg/kg caused mild hematologic (blood) effects. No effects were seen at 20 mg/kg. Liver carcinomas were observed in a lifetime inhalation study in which mice and rats were exposed to MEKO 6 hrs/day, 5 days/week for 18 months and 26 months, respectively. These carcinomas were statistically increased in males at a MEKO concentration of 375 ppm. In addition, degenerative effects on the olfactory epithelium of the nasal passages occurred in a concentration related manner in males and females of both species at MEKO concentrations of 15, 75, and 375 ppm. The relevance of this data to human health is unknown. OTHER EFFECTS OF OVEREXPOSURE: None currently known.