CV-1148

SECTION 2: Hazards identification

EFFECTS OF SINGLE OVEREXPOSURE: SWALLOWING: Slightly toxic. May cause nausea, abdominal discomfort, vomiting, and diarrhea. Swallowing of a large quantity may lead to central nervous system disturbances, such as convulsions, depression, or coma. Aspiration into the lungs may occur during ingestion or vomiting, resulting in lung injury. SKIN ABSORPTION: No evidence of adverse effects from available information. INHALATION: Vapor is irritating, experienced as nasal discomfort and discharge, and may cause headache, giddiness, and unconsciousness. Severe overexposure by inhalation may result in permanent lung damage. SKIN CONTACT: Brief contact is not irritating. Prolonged contact, as from clothing wet with the material, may cause moderate irritation seen as local redness. EYE CONTACT: Liquid causes irritation, seen as excess redness and swelling of the conjunctiva. High vapor concentrations cause tearing and irritation. EFFECTS OF REPEATED OVEREXPOSURE: Inhalation over a prolonged period will produce symptoms of dizziness, weakness, pain in the limbs, paresthesias, and nervousness, and lead to anemia and weight loss. No injury from silica or other dust should occur during reasonable use. If use creates respirable particles, some respiratory system injury may occur. However, since the silica in this product is compounded into the polymer matrix, it is not expected to present the same health hazard as neat silica.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE Because of its irritating and defatting properties, this material may aggravate an existing dermatitis. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: Prolonged and repeated inhalation exposure to hydrocarbon vapor in the same boiling range has produced kidney damage in male rats. This effect has not been observed in female rats and male and female mice. The relevance of this information to humans is unknown. In a subchronic oral toxicity animal study, methyl ethyl ketoxime (MEKO), which is given off during cure, produced an adverse effect upon red blood cells (anemia). This was found for all dose levels tested. In an acute dermal animal study, 200 mg/kg caused mild hematologic (blood) effects. No effects were seen at 20 mg/kg. Liver carcinomas were observed in a lifetime inhalation study in which mice and rats were exposed to MEKO 6 hrs/day, 5 days/week for 18 months and 26 months, respectively. These carcinomas were statistically increased in males at a MEKO concentration of 375 ppm. In addition, degenerative effects on the olfactory epithelium of the nasal passages occurred in a concentration related manner in males and females of both species at MEKO concentrations of 15, 75, and 375 ppm. The relevance of this data to human health is unknown. OTHER EFFECTS OF OVEREXPOSURE: None known.