CF2-137

SECTION 2: Hazards identification

EFFECTS OF SINGLE OVEREXPOSURE: SWALLOWING: Slightly toxic. May cause nausea, abdominal discomfort, vomiting, and diarrhea. Swallowing of large quantity may lead to central nervous system disturbances, such as convulsions, depression, or coma. Aspiration into the lungs may occur during ingestion or vomiting, resulting in lung injury. SKIN ABSORPTION: No evidence of adverse effects from available information. INHALATION: Causes irritation of the respiratory tract, experienced as nasal discomfort and discharge with chest pain and coughing. Dizziness and drowsiness may occur. Eye irritation may occur. Severe overexposure by inhalation may result in permanent lung damage. SKIN CONTACT: Brief contact is not irritating. Prolonged contact, as from clothing wet with the material, may cause moderate irritation seen as local redness and may burn slightly. EYE CONTACT: Liquid causes irritation, experienced as stinging, excess blinking and tear production, with excess redness and swelling of the conjunctiva. High vapor concentrations may cause irritation, experienced as stinging, excess blinking and tear production, with excess redness of the conjunctiva. EFFECTS OF REPEATED OVEREXPOSURE: Inhalation over a prolonged period will produce symptoms of dizziness, weakness, pain in the limbs, paresthesias, nervousness, and lead to anemia and weight loss. Repeated overexposure to Tetra (2-methoxyethoxy) silane may cause injury to bone marrow, blood cells, and testes.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE Because of its irritating and defatting properties, this material may aggravate an existing dermatitis. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: Prolonged and repeated inhalation exposure to hydrocarbon vapor in the same boiling range has produced kidney damage in male rats. This effect has not been observed in female rats and male and female mice. The relevance of this information to humans is unknown. The EPA has expressed concern regarding the possible adverse health effects resulting from the inhalation of alkoxylsilanes and has recommended that administrative and mechanical means be used to minimize exposures. n-Propanol (which is generated upon exposure to water and/or moisture) has been demonstrated to be carcinogenic in lifetime exposure studies in rats when administered orally or subcutaneously. In laboratory inhalation studies of Tetra (2-methoxyethoxy) silane, increased fetal lethality, and delayed fetal development have been observed in offspring of female animals exposed to concentrations in air of 50 ppm and higher. OTHER EFFECTS OF OVEREXPOSURE: None currently known.