ZINC OXIDE

Other physicochemical hazards

The data available does not support any physical or chemical hazard.

Environmental hazards

R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Potential health effects

Inhalation : May cause irritation to the respiratory tract. - Skin contact : Repeated or prolonged skin contact may cause irritation. - Eye contact : Excessive dust exposure may cause minor eyes irritation. - Ingestion :

Health hazards

if ingested in large quantities, can cause abdominal pain, nausea, cramps. SECTION 5 – FIRE, FIGHTING & EXPLOSION DATA Fire: Non Combustible. Flammability: Non Flammable Flash point: Not combustible Extinguishing media: In case of fire in immediate vicinity use any extinguishing agent. Protection of fire-fighters: Use breathing apparatus (self-contained breathing apparatus with full face shield). Wear suitable protective clothing. Hazardous combustion and: None. decomposition products SECTION 6 - STABILITY & REACTIVITY DATA Stability: Stable under ordinary conditions Hazardous Reactions: None Incompatibility (materials to avoid): 1. Heated Magnesium 2. Chlorinated Rubber above 215c 3. Acids and Bases

TOXICOLOGICAL INFORMATION

Acute toxicity - Inhalation: (rat) 4 hours LC50 > 5.7 mg ZnO/l Klimisch et al. 1982 - Dermal: No data available. - Ingestion: (rat) LD50 >15000 mg ZnO/kg OECD 401 Dermal irritation (rabbit): Not irritant. OECD 404 Eyes irritation (rabbit): Not irritant. OECD 405 Chronic toxicity: 50 mg ZnO/ day (Section 7 continued-Toxilogical Information) Page 3 of 5 Sensitization: (guinea-pig) This product has been reported not to cause skin sensitization (Magnusson & Kligman) Carcinogenicity: No evidence of carcinogenicity in laboratory animals. No evidence of carcinogenicity in man. Mutagenicity: In vitro and in vivo test of short-term genotoxicity : no evidence of genotoxicity. Reproductive toxicity: No experimental or epidemiological evidence of reproduction toxicity.

Teratogenic Effects

Other toxicoligical information: Zinc fume fever is attributable to exposure to ultra-fine zinc oxide particles (generated for example during welding and cutting of galvanised steel), but is not experienced in inhalation exposure to commercially traded Zinc Oxide. Rat inhalation LC50 [mg/l/4h]: > 5.7 ZnO