This Standard Reference Material (SRM) is a gravimetrically prepared single-compound

NFPA Ratings

Scale 0-4) Health = 2 Fire = 3 Reactivity = 0

Health hazards

Skin, eye, and respiratory irritation, central nervous system depression, aspiration hazard, and nerve damage.

Physical hazards

Flammable liquid and vapor. Vapor may cause flash fire

Potential health effects

Acute and Chronic) Inhalation: Methanol can cause irritation of the mucous membranes, coughing, ringing in the ears, constipation, recurrent headaches, drowsiness, dizziness, tingling sensation, tremors, loss of coordination, enlargement of the liver, blood disorders, oppression in the chest, tracheitis, bronchitis, tinnitus, unsteady gait, twitching, colic, nystagmus, blepharospasm, and nerve damage. Occupational exposure symptoms include paresthesias, numbness and shooting pains in the hands and forearms. Metabolic acidosis and effects on the eyes and central nervous system may occur. Toluene can cause irritation, nausea, headache, drowsiness, dizziness, disorientation, sleep disturbances, loss of coordination, dilated pupils, kidney damage, and liver damage. Skin Contact: Methanol can cause irritation; skin absorption may occur and cause metabolic acidosis and effects on the eyes and central nervous system. Repeated or prolonged contact may cause defatting of the skin resulting in erythema, scaling, and eczematoid dermatitis. Chronic absorption may result in headache, drowsiness, dizziness, loss of coordination, and blood disorders. Eye Contact: Methanol vapors may cause irritation and eye damage. Concentrated solutions have been reported to cause violent inflammation of the conjunctiva and epithelial defects on the cornea. Repeated or prolonged contact may cause conjunctivitis. Ingestion: Ingestion of methanol may result in mild and transient inebriation and subsequent drowsiness. Liver, kidney, heart, stomach, intestine and pancreatic damage may also occur. Death may occur due to respiratory failure. As little as 15 mL has caused blindness; the usual fatal dose is 60–240 mL. Toluene can cause irritation, nausea, stomach pain, headache, drowsiness, dizziness, disorientation, sleep disturbances, loss of coordination, dilated pupils, kidney damage, and liver damage. Potential aspiration hazard if ingested. Listed as a Carcinogen/Potential Carcinogen Yes No In the National Toxicology Program (NTP) Report on Carcinogens X In the International Agency Report on Carcinogens (IARC) Monographs X(a) By the Occupational Safety and Health Administration (OSHA) X (a) IARC lists toluene as Group 3 (not classifiable). 3. COMPOSITION AND INFORMATION ON HAZARDOUS INGREDIENTS Component CAS Registry EC Number Nominal Mass Concentration(a) (EINECS) (%) Methanol 67-56-1 200-659-6 99 Toluene 108-88-3 203-625-9 1