AFRIN/DURATION-Oxymetazoline Nasal Sprays

SECTION 2: Hazards identification

OSHA EMERGENCY OVERVIEW Liquid Clear, Colorless Characteristic odor May be harmful if swallowed. May cause effects to: central nervous system cardiovascular system Consumers: Refer to the package insert or product label for appropriate consumer-specific information about this product when used according to manufacturer's directions.

Potential health effects

Oxymetazoline nasal sprays may cause central nervous system and cardiac effects if not used according to manufacturer's directions. The health hazard information presented below is for the active ingredient in this product. Oxymetazoline is a potent decongestant drug active that causes vasoconstriction and cardiac effects. It is highly toxic by acute inhalation, ocular, and oral exposure. Ingestion of oxymetazoline hydrochloride causes systemic effects including adverse cardiovascular symptoms (palpitations, hypertension, or slow heart beat) and central nervous system symptoms (dizziness, spastic paralysis, insomnia, central nervous system depression) as well as cyanosis. There is limited repeated-dose toxicity data available. No known adverse effects to the fetus have been demonstrated after oxymetazoline exposure to pregnant women. Oxymetazoline has been reported to have addictive properties and patient abuse has resulted in severe central nervous system effects including amphetamine-like properties and associated paranoid psychosis and secondary mania. In laboratory animals, oxymetazoline was shown to be slightly irritating to the eyes and not-sensitizing on the skin. It has caused adverse cardiac conduction, increased blood pressure, and slow heartbeat. LISTED CARCINOGENS No carcinogens or potential carcinogens listed by