MS-122RA

SECTION 2: Hazards identification

Milky, white, liquid with a faint ethereal odor, packaged in an aerosol container.

Potential health effects

2,3-Dihydrodecafluoropentane INHALATION: Gross overexposure by inhalation may cause suffocation if air is displaced by vapors and central nervous system stimulation with increased activity or sleeplessness, tremors or convulsions. These effects may be followed by central nervous system depression with dizziness, confusion, incoordination, drowsiness or unconsciousness. Based on data from other fluorocarbons, gross overexposure to HFC-43-10mee may cause irregular heart beat or heart rhythm, which may produce heart palpitation, dizziness, weakness, sometimes progressing to loss of consciousness and death. It is unlikely that concentrations sufficient to produce irregular heartbeat or heart rhythm would be achieved from HFC-43-10mee without first producing other signs of toxicity. Page 2 of 8 MS-122RA DPMS-Z0624A SKIN: Immediate effects of overexposure by skin contact may include slight irritation with itching, redness or swelling. Repeated and/or prolonged exposure may cause defatting of the skin with itching, redness or rash. Based on animal data, significant skin permeation, and systemic toxicity after skin contact, appears unlikely. EYE: Immediate effects of overexposure by eye contact may include eye irritation with tearing, pain or blurred vision. INGESTION: The major ingestion hazard is aspiration (liquid entering the lungs during ingestion or vomiting) which may result in "chemical pneumonia." Symptoms include coughing, gasping, choking, shortness of breath, bluish discoloration of the skin, rapid breathing and heart rate, and fever. Pulmonary edema or bleeding, drowsiness, confusion, coma and seizures may occur in more serious cases. Symptoms may develop immediately or as late as 24 hours after exposure, depending on how much of the chemical entered the lungs. Increased susceptibility to the effects may be observed in persons with pre-existing disease of the central nervous system or the cardiovascular system. 3,3 Dichloro-1,1,1,2,2-pentafluoropropane Data from acute toxicity studies indicate that 3,3-dichloro-1,1,1,2,2-pentafluoropropane (HCFC-225ca) does not cause eye irritation nor dermal toxicity in standardized tests; skin application at high doses (2,000 mg/kg body weight) produces no adverse effects. Therefore, the dermal LD50s are greater than 2,000 mg/kg body weight. Oral administration at high doses (5,000 mg/kg body weight) does not cause any mortality and the LD50s are greater than 5,000 mg/kg body weight. AK-225ca has very low acute inhalation toxicity as measured by the concentration that cause 50% mortality in experimental animals. In 28-day inhalation studies with rats, the activity and responsiveness of the animals was reduced at 5,000 ppm or greater. Toxicity was otherwise confined to the liver; liver enlargement and induction of peroxisomes was seen following treatment. In a 28-day study with marmoset , exposure to HCFC-225ca at 1,000ppm caused effects on the liver, such as slight fat deposition associated with changes in serum biochemical parameters. However, no liver enlargement was seen and virtually no peroxisome induction was observed. Animal testing with HCFC-225ca indicates that the material is not teratogenic. In one in-vitro study with mammalian cell cultures (human lympocytes) HCFC-225ca caused genetic damage; However the overall evidence from these studies implies that the isomer is not genotoxic.. 1,1,1,2-Tetrafluoroethane 1,1,1,2-tetrafluoroethane is untested for skin and eye irritation, and is untested for animal sensitization. No toxic effects were seen in animals from exposure by inhalation to concentrations up to 81,000 ppm. Lethargy and rapid respiration were observed at a vapor concentration of 205,000 ppm and pulmonary congestion, edema, and central nervous system effects occurred at a vapor concentration of 750,000 ppm. Cardiac sensitization occurred in dogs at 75,000 ppm from the action of exogenous epinephrine. No adverse effects were observed in male and female rats fed 300 mg/kg/day of tetrafluoroethane for 52 weeks. Animal testing indicates that this compound does not have carcinogenic, or mutagenic effects. Embryotoxic activity has been observed in some animal tests but only at maternally toxic dose levels. Tetrafluoroethylene Telomer Inhalation of PTFE dust may cause generalized irritation of the nose, throat, and lungs with cough, difficulty in breathing or shortness of breath. Inhalation of fluorine compounds released as decomposition products above 290°C (554°F) may cause lung irritation and pulmonary edema, which require medical treatment. Inhalation of fumes or smoke from overheated or burning Poly-TFE may cause polymer fume fever, a temporary flu-like illness accompanied by fever, chills, and sometimes cough, of approximately 24 hour in duration. Repeated episodes of polymer fume fever may cause lung damage. Page 3 of 8 MS-122RA DPMS-Z0624A