Naproxen impurity standard, British Pharmacopoeia (BP) Reference Standard

Hazard statements (CLP)

H302, H314, H317, H318, H335, H360, H411

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 Classification of the substance or mixture

Signal word

Danger Danger

Hazard statements

H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H335 May cause respiratory irritation. H360 May damage fertility or the unborn child. H411 Toxic to aquatic life with long lasting effects. H317 May cause an allergic skin reaction. H360 May damage fertility or the unborn child. H314 Causes severe skin burns and eye damage.

Precautionary statements

Prevention: P260 Do not breathe dust. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P260 Do not breathe dust. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Response

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Hazardous Ingredients

6-Methoxy-2-naphthoic acid (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt 2-Bromomethylnaphthalene 6-Methoxy-α-methyl-2-naphthalenemethanol Reduced Labelling (<= 125 ml)

Supplemental label elements

none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Classification (REGULATION (EC) No 1272/2008) Acute toxicity, Category 4 H302: Harmful if swallowed. Skin corrosion, Sub-category 1B H314: Causes severe skin burns and eye damage. Serious eye damage, Category 1 H318: Causes serious eye damage. Skin sensitisation, Category 1 H317: May cause an allergic skin reaction. Reproductive toxicity, Category 1A H360: May damage fertility or the unborn child. Specific target organ toxicity - H335: May cause respiratory irritation. single exposure, Category 3, Respiratory system Long-term (chronic) aquatic hazard, H411: Toxic to aquatic life with long lasting Category 2 effects.