Methotrexate

Hazard statements (CLP)

H301, H341, H360D, H372

Code

Statements

H301

Toxic if swallowed

SECTION 2: Hazards identification

Labelling according Regulation (EC) No 1272/2008 as amended by GB-CLP Classification of the substance or mixture

Signal word

Danger Danger

Hazard statements

H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H360D May damage the unborn child. H372 Causes damage to organs (Liver, Bone marrow) through prolonged or repeated exposure. H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H372 Causes damage to organs through prolonged or repeated exposure. H360D May damage the unborn child.

Precautionary statements

P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P405 Store locked up. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P405 Store locked up.

Supplemental label elements

none Reduced Labeling (<= 125 ml) none

Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 as amended by GB-CLP Regulation, UK SI 2019/720, and UK SI 2020/1567 Acute toxicity, (Category 3) H301: Toxic if swallowed. Germ cell mutagenicity, H341: Suspected of causing genetic (Category 2) defects. Reproductive toxicity, (Category H360D: May damage the unborn child. 1B) Specific target organ toxicity - H372: Causes damage to organs through repeated exposure, (Category 1), prolonged or repeated exposure. Liver, Bone marrow