Note: Ingredients listed on restricted chemical lists
EC/CAS
200-413-8
Name of the chemical
Methotrexate (INN)
Concentration
<= 100 %
General Information
Version
7.0
Revision date
2024-04-02
Product name
Methotrexate
CAS No.
59-05-2
REACH No
is
1.2.1 Relevant identified uses
Reagent for development and research
Emergency telephone
+(44)-870-8200418, +(353)-19014670, 001-803-017-9114
Icons in SDS
Company Information
company name
Merck KGaA
e-mail address of the competent person responsible for the Safety Data Sheet
TechnicalService@merckgroup.com
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H301, H341, H360D, H372
Hazard statements
Code
Statements
H301
Toxic if swallowed
Section 2
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Acute toxicity, (Category 3) H301: Toxic if swallowed. Germ cell mutagenicity, H341: Suspected of causing genetic (Category 2) defects. Reproductive toxicity, (Category H360D: May damage the unborn child. 1B) Specific target organ toxicity - H372: Causes damage to organs through repeated exposure, (Category 1), prolonged or repeated exposure. Liver, Bone marrow
2.2 Label elements
Labelling
Signal word
Danger Danger
Hazard statements
H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H360D May damage the unborn child. H372 Causes damage to organs (Liver, Bone marrow) through prolonged or repeated exposure. H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H372 Causes damage to organs through prolonged or repeated exposure. H360D May damage the unborn child.
Precautionary statements
P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P405 Store locked up. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P405 Store locked up.
Supplemental label elements
none Reduced Labeling (<= 125 ml) none
Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
ECOLOGICAL INFORMATION
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
TOXICOLOGICAL INFORMATION
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
