2-Methoxyestradiol

Merck Life Science UK Limited

Revision date : 2025-11-05

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GHS09 GHS08 GHS06
Health risk rating 5
Safety risk rating 1
Environmental risk rating 5

General Information

Version

6.8

Revision date

2025-11-05

Product name

2-Methoxyestradiol

CAS No.

362-07-2

REACH No

A

Emergency telephone

+44 (0)870 8200418

Icons in SDS

GHS06 GHS08 GHS09 M004 M009 M017

Company Information

company name

Merck Life Science UK Limited

e-mail address of the competent person responsible for the Safety Data Sheet

TechnicalService@merckgroup.com

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H301, H301+H311+H331, H311, H315, H319, H331, H335, H350, H360, H372, H400, H410

Hazard statements

Code

Statements

H301

Toxic if swallowed

Section 2

SECTION 2: Hazards identification

Labelling according Regulation (EC) No 1272/2008 as amended by GB-CLP Classification of the substance or mixture

Signal word

Danger Danger

Hazard statements

H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H350 May cause cancer. H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. Reduced Labelling (<= 125 ml) H350 May cause cancer. H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.

Precautionary statements

P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/ doctor if you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/ doctor if you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor.

Supplemental label elements

none none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 as amended by GB-CLP Regulation, UK SI 2019/720, and UK SI 2020/1567 Acute toxicity, (Category 3) H301: Toxic if swallowed. Acute toxicity, (Category 3) H331: Toxic if inhaled. Acute toxicity, (Category 3) H311: Toxic in contact with skin. Skin irritation, (Category 2) H315: Causes skin irritation. Eye irritation, (Category 2) H319: Causes serious eye irritation. Carcinogenicity, (Category 1B) H350: May cause cancer. Reproductive toxicity, (Category H360: May damage fertility or the unborn 1B) child. Specific target organ toxicity - H335: May cause respiratory irritation. single exposure, (Category 3), Respiratory system Specific target organ toxicity - H372: Causes damage to organs through repeated exposure, (Category 1) prolonged or repeated exposure. Short-term (acute) aquatic H400: Very toxic to aquatic life. hazard, (Category 1) Long-term (chronic) aquatic H410: Very toxic to aquatic life with long hazard, (Category 1) lasting effects.

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