Note: Ingredients listed on restricted chemical lists
EC/CAS
123-91-1
Name of the chemical
1,4-Dioxane
Concentration
>=30-<=60
General Information
Version
8.12
Revision date
2026-07-14
Product name
1,4-Dioxane solution
1.2.1 Relevant identified uses
Laboratory chemicals, Synthesis of substances
Emergency telephone
800-424-9300, +1-703- 527-3887
Icons in SDS
Company Information
company name
Sigma-Aldrich Inc
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H225, H304, H315, H319, H335, H340, H350, H372, H401, H412
Hazard statements
Code
Statements
H225
Highly Flammable liquid and vapour
Section 2
SECTION 2: Hazards identification
Aspiration hazard
Category 1 Short-term (acute) Category 2 aquatic hazard Long-term (chronic) Category 3 aquatic hazard Other hazards May form explosive peroxides
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour. H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H340 May cause genetic defects. H350 May cause cancer. H372 Causes damage to organs (Blood) through prolonged or repeated exposure. H401 Toxic to aquatic life. H412 Harmful to aquatic life with long lasting effects.
Prevention
P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof electrical/ ventilating/ lighting P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe mist or vapours. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P331 Do NOT induce vomiting. P332 + P313 If skin irritation occurs: Get medical P337 + P313 If eye irritation persists: Get medical P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P403 + P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal
P501 Dispose of contents/ container to an approved waste disposal plant.
2.1 Classification of the substance or mixture
(29 CFR 1910.1200) Hazards for the product as supplied Flammable liquids : Category 2 Skin irritation : Category 2 Eye irritation : Category 2A Germ cell mutagenicity : Category 1B Carcinogenicity : Category 1A Specific target organ : Category 3 (Respiratory system) toxicity - single exposure Specific target organ : Category 1 (Blood) toxicity - repeated exposure Aspiration hazard : Category 1 Short-term (acute) : Category 2 aquatic hazard Long-term (chronic) : Category 3 aquatic hazard Other hazards May form explosive peroxides.