1,4-Dioxane

Merck Life Science AS

Revision date : 2025-12-25

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GHS02 GHS08 GHS07
Health risk rating 5
Safety risk rating 5
Environmental risk rating 1

Note: Ingredients listed on restricted chemical lists

General Information

Version

8.5

Revision date

2025-12-25

Product name

1,4-Dioxane

CAS No.

123-91-1

REACH No

01-2119462837-26-XXXX

Emergency telephone

+(47)-22591300, +(47)-21930678

Icons in SDS

GHS02 GHS07 GHS08 M004 M009 M010 M011 M017

Company Information

company name

Merck Life Science AS

e-mail address of the competent person responsible for the Safety Data Sheet

TechnicalService@merckgroup.com

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H225, H319, H335, H350

Hazard statements

Code

Statements

H225

Highly Flammable liquid and vapour

Section 2

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 Classification of the substance or mixture

Signal word

Danger Danger

Hazard statements

H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H350 May cause cancer. EUH066 Repeated exposure may cause skin dryness or cracking. H350 May cause cancer.

Supplemental label elements

EUH019 May form explosive peroxides. EUH019 May form explosive peroxides. EUH066 Repeated exposure may cause skin dryness or cracking.

Precautionary statements

P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P202 Do not handle until all safety precautions have been read and understood. P308 + P313 IF exposed or concerned: Get medical advice/ attention.

Response

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention.

Additional information

Restricted to professional users. Reduced Labelling (<= 125 ml)

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Classification (REGULATION (EC) No 1272/2008) Flammable liquids, Category 2 H225: Highly flammable liquid and vapour. Eye irritation, Category 2 H319: Causes serious eye irritation. Carcinogenicity, Category 1B H350: May cause cancer. Specific target organ toxicity - H335: May cause respiratory irritation. single exposure, Category 3,

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