Vorinostat Formulation

Hazard statements (CLP)

H341, H360FD, H372, H410

Code

Statements

H341

Suspected of causing genetic defects

2.1 Classification of the substance or mixture

Germ cell mutagenicity Category 2 Reproductive toxicity Category 1B Specific target organ toxicity - Category 1 (Blood, thymus gland, Bone marrow, spleen, Gas- repeated exposure (Oral) trointestinal tract) Short-term (acute) aquatic Category 1 Long-term (chronic) aquatic Category 1

Signal word

Danger

Hazard statements

H341 Suspected of causing genetic defects. H360FD May damage fertility. May damage the unborn child. H372 Causes damage to organs (Blood, thymus gland, Bone marrow, spleen, Gastrointestinal tract) through prolonged or repeated exposure if swallowed. H410 Very toxic to aquatic life with long lasting effects.

Prevention

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protec- tion/ face protection.

Response

P308 + P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/ container to an approved waste disposal plant.

Other hazards which do not result in classification

Dust contact with the eyes can lead to mechanical irritation. Contact with dust can cause mechanical irritation or drying of the skin. May form explosive dust-air mixture during processing, handling or other means.