Dimethyl fumarate

Hazard statements (CLP)

H302, H315, H317, H319, H401

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

GHS Classification in Accordance with 29 CFR 1910 (OSHA HCS): Classification of the substance or mixture

Hazard statements

H302 Harmful if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H401 Toxic to aquatic life

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

2.3 Other hazards

None.

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) Acute toxicity, oral (Category 4),H302 Skin corrosion/irritation (Category 2),H315 Sensitisation, skin (Category 1, 1A, 1B),H317 Serious eye damage/eye irritation (Category 2A),H319 Hazardous to the aquatic environment, acute hazard (Category 2),H401 2.2 GHS Label elements, including precautionary statements Pictogram Signal word Warning Hazard statement(s) H302 Harmful if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H401 Toxic to aquatic life Precautionary statement(s) P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. 2.3 Other hazards None. 3. COMPOSITION/INFORMATION ON INGREDIENTS 3.1 Substances Formula: C6H8O4 Molecular Weight: 144.13 CAS No. : 624-49-7 4. FIRST AID MEASURES 4.1 Description of first aid measures Eye contact Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician. Skin contact Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician. Inhalation Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth- to-mouth resuscitation. Ingestion Wash out mouth with water; Do NOT induce vomiting; call a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2). 4.3 Indication of any immediate medical attention and special treatment needed Treat symptomatically. 5. FIRE FIGHTING MEASURES 5.1 Extinguishing media Suitable extinguishing media Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher. 5.2 Special hazards arising from the substance or mixture During combustion, may emit irritant fumes. 5.3 Advice for firefighters Wear self-contained breathing apparatus and protective clothing. 6. ACCIDENTAL RELEASE MEASURES 6.1 Personal precautions, protective equipment and emergency procedures Use full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Refer to protective measures listed in sections 8. 6.2 Environmental precautions Try to prevent further leakage or spillage. Keep the product away from drains or water courses. 6.3 Methods and materials for containment and cleaning up Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13. 7. HANDLING AND STORAGE 7.1 Precautions for safe handling Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition. Recommended storage temperature: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Shipping at room temperature if less than 2 weeks. 7.3 Specific end use(s) No data available. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control parameters Components with workplace control parameters This product contains no substances with occupational exposure limit values. 8.2 Exposure controls Engineering controls Ensure adequate ventilation. Provide accessible safety shower and eye wash station. Personal protective equipment Eye protection Safety goggles with side-shields. Hand protection Protective gloves. Skin and body protection Impervious clothing. Respiratory protection Suitable respirator. Environmental exposure controls Keep the product away from drains, water courses or the soil. Clean spillages in a safe way as soon as possible. 9. PHYSICAL AND CHEMICAL PROPERTIES 9.1 Information on basic physical and chemical properties Appearance Solid Odor No data available Odor threshold No data available pH No data available Melting/freezing point 102-106°C Boiling point/range 192-193°C at 760 mmHg Flash point No data available Evaporation rate No data available Flammability (solid, gas) No data available Upper/lower flammability or explosive limits No data available Vapor pressure No data available Vapor density No data available Relative density No data available Water Solubility No data available Partition coefficient No data available Auto-ignition temperature No data available Decomposition temperature No data available Viscosity No data available Explosive properties No data available Oxidizing properties No data available 9.2 Other safety information No data available. 10. STABILITY AND REACTIVITY 10.1 Reactivity No data available. 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available. 10.4 Conditions to avoid No data available. 10.5 Incompatible materials Strong acids/alkalis, strong oxidising/reducing agents. 10.6 Hazardous decomposition products Under fire conditions, may decompose and emit toxic fumes. Other decomposition products - no data available. 11.TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity Classified based on available data. For more details, see section 2 Skin corrosion/irritation Classified based on available data. For more details, see section 2 Serious eye damage/irritation Classified based on available data. For more details, see section 2 Respiratory or skin sensitization Classified based on available data. For more details, see section 2 Germ cell mutagenicity Classified based on available data. For more details, see section 2 Carcinogenicity IARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH. NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP. OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA. Reproductive toxicity Classified based on available data. For more details, see section 2 Specific target organ toxicity - single exposure Classified based on available data. For more details, see section 2 Specific target organ toxicity - repeated exposure Classified based on available data. For more details, see section 2 Aspiration hazard Classified based on available data. For more details, see section 2 Additional information RTECS No.: EM6125000 This information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been completely investigated. 12. ECOLOGICAL INFORMATION 12.1 Toxicity No data available. 12.2 Persistence and degradability