Diazyme Administration

S-phrase(s)

Reagent 1 Trizma Base 1.21 % 67-48-1 200-655-4 Xi 36/37/38 26/36 N/A Reagent 1 N/A Glycerol 2.5 % 56-81-5 200-289-5 N/A Reagent 1 Sodium Azide 0.09 % 26628-22-8 247-852-1 T+ 28/32/50/53 28/45/60/61 Reagent 1 Choline Chloride 17 % 67-48-1 200-655-4 Xi 36/37/38 26/36 Reagent 2 Sodium Azide 0.09 % 26628-22-8 247-852-1 T+ 28/32/50/53 28/45/60/61 Calibrator Sodium Azide 0.09 % 26628-22-8 247-852-1 T+ 28/32/50/53 28/45/60/61 28/32/50/53 28/45/60/61 Control Sodium Azide 0.09 % 26628-22-8 247-852-1 T+ NOTE: Physical and health hazard information on reagent mixtures has not been determined. Any physical and health information noted is based on 1) evaluation of data for the pure ingredients, and 2) concentration of ingredients as packaged. SECTION 3: HAZARD IDENTIFICATION TRIZMA BASE: Emergency Overview OSHA Hazards Irritant GHS Classification Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3) GHS Label elements, including precautionary statements Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. HMIS Classification Health hazard: 2 Flammability: 0 Physical hazards: 0 NFPA Rating Health hazard: 2 Fire: 0 Reactivity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Skin May be harmful if absorbed through skin. Causes skin irritation. Eyes Causes eye irritation. Ingestion May be harmful if swallowed. Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), H335 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC Xi Irritant R36/37/38 For the full text of the R-phrases mentioned in this Section, see Section 16. 2.2 Label elements Labeling according Regulation (EC) No 1272/2008 Pictogram Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. Sigma - T1503 Page 2 of 7 H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements none 2.3 Other hazards - none SODIUM AZIDE: Emergency Overview OSHA Hazards Target Organ Effect, Highly toxic by ingestion, highly toxic by skin absorption Target Organs Heart, Central nervous system, Brain. Other hazards which do not result in classification Sodium Azide may react with lead and copper plumbing to form highly explosive metal azides. Rapidly absorbed through skin. GHS Classification Acute toxicity, Oral (Category 2) Acute toxicity, Dermal (Category 1) Acute aquatic toxicity (Category 1) Chronic aquatic toxicity (Category 1) GHS Label elements, including precautionary statements Pictogram Signal word Danger Hazard statement(s) H300 + H310 Fatal if swallowed or in contact with skin H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P264 Wash hands thoroughly after handling. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing. P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water. P310 Immediately call a POISON CENTER or doctor/ physician. P501 Dispose of contents/ container to an approved waste disposal plant. Other hazards Contact with acids liberates very toxic gas. HMIS Classification Health hazard: 4 Chronic Health Hazard: * Flammability: 0 Physical hazards: 0 NFPA Rating Health hazard: 4 Fire: 0 Reactivity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be fatal if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Ingestion May be fatal if swallowed. Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 2) Acute aquatic toxicity (Category 1) Chronic aquatic toxicity (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Very toxic if swallowed. Contact with acids liberates very toxic gas. Very toxic to aquatic organisms may cause long-term adverse effects in the aquatic environment. Label elements Labeling according Regulation (EC) No 1272/2008 [CLP] Signal word Danger Hazard statement(s) H300 Fatal if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P264 Wash hands thoroughly after handling. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ P501 Dispose of contents/ container to an approved waste disposal plant. Supplemental Hazard information (EU) EUH032 Contact with acids liberates very toxic gas. According to European Directive 67/548/EEC as amended. R-phrase(s) R28 Very toxic if swallowed. R32 Contact with acids liberates very toxic gas. R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S-phrase(s) S28 After contact with skin, wash immediately with plenty of soap and water. S45 In case of accident or if you feel unwell, seek medical advice immediately (Show the label where possible). S60 This material and its container must be disposed of as hazardous waste. S61 Avoid release to the environment. Refer to special instructions/ Safety data sheets. 2.3 Other hazards Sodium Azide may react with lead and copper plumbing to form highly explosive metal azides. Rapidly absorbed through skin. GLYCEROL: Emergency Overview OSHA Hazards Target Organ Effect Target Organs Kidney GHS Classification Skin irritation (Category 3) Eye irritation (Category 2B) GHS Label elements, including precautionary statements Pictogram none Signal word Warning Hazard statement(s) H316 Causes mild skin irritation. H320 Causes eye irritation. Precautionary statement(s) P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. HMIS Classification Health hazard: 0 Chronic Health Hazard: * Flammability: 1 Physical hazards: 0 NFPA Rating Health hazard: 0 Fire: 1 Reactivity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Ingestion May be harmful if swallowed. Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC. Label elements The product does not need to be labeled in accordance with EC directives or respective national laws. Other hazards – none CHOLINE CHLORIDE: Emergency Overview OSHA Hazards Irritant GHS Classification Acute toxicity, Oral (Category 5) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3) GHS Label elements, including precautionary statements Pictogram Signal word Warning Hazard statement(s) H303 May be harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. HMIS Classification Health hazard: 2 Flammability: 0 Physical hazards: 0 NFPA Rating Health hazard: 2 Fire: 0 Reactivity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Skin May be harmful if absorbed through skin. Causes skin irritation. Eyes Causes eye irritation. Ingestion May be harmful if swallowed. Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Skin irritation (Category 2) Eye irritation (Category 2) Specific target organ toxicity - single exposure (Category 3) Classification is according to EU Directives 67/548/EEC or 1999/45/EC Irritating to eyes, respiratory system and skin. Label elements Labeling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard: none Statements According to European Directive 67/548/EEC as amended. R-phrase(s) R36/37/38 Irritating to eyes, respiratory system and skin. S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 Wear suitable protective clothing. Other hazards - none