NucleoSpin miRNA (250)

MACHEREY-NAGEL GmbH & Co. KG

Revision date : 2021-05-12

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GHS02 GHS05 GHS07 GHS08 GHS09
Health risk rating 5
Safety risk rating 3
Environmental risk rating 4

Note: Ingredients listed on restricted chemical lists

EC/CAS

64-17-5

Name of the chemical

Ethanol

Concentration

N/A

EC/CAS

123-91-1

Name of the chemical

1,4-Dioxane

Concentration

N/A

EC/CAS

7732-18-5

Name of the chemical

Water, distilled, conductivity or of similar purity H2O

Concentration

N/A

EC/CAS

231-791-2

Name of the chemical

Water, distilled, conductivity or of similar purity H2O

Concentration

N/A

EC/CAS

204-661-8

Name of the chemical

1,4-Dioxan (2021/849)

Concentration

N/A

General Information

Revision date

2021-05-12

Product name

NucleoSpin miRNA (250)

REACH No

see

1.2.2. Uses advised against

not described

Manufacturer Name

MACHEREY-NAGEL GmbH & Co. KG

Emergency telephone

Outside Germany (DE): Call your regional Poisons Information Service or call local Life Saving Service

Icons in SDS

Company Information

company name

MACHEREY-NAGEL GmbH & Co. KG

e-mail address of the competent person responsible for the Safety Data Sheet

sds@mn-net.com (m

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H225, H226, H302, H314, H315, H319, H332, H334, H335, H351, H411, H412

Hazard statements

Code

Statements

H225

Highly Flammable liquid and vapour

Section 2

SECTION 2: Hazards identification

2.0 Classification of the complete product GHS02 GHS07 GHS08 GHS09

Signal word

DANGER Hazard classes/categories H225 Flam. Liq. 2 H226 Flam. Liq. 3 H302 Acute Tox. 4 oral H315 Skin Irrit. 2 H319 Eye Irrit. 2 H334 Resp. Sens. 1 H335 STOT SE 3 H351 Carc. 2 H411 Aquatic Chronic 2 H412 Aquatic Chronic 3 - No hazard class 125 mL MDB GHS02 WARNING Hazard classes/categories H226 Flam. Liq. 3 125 mL ML GHS07 WARNING Hazard classes/categories H302 Acute Tox. 4 oral H412 Aquatic Chronic 3 100 mL MP GHS07 GHS09 WARNING Hazard classes/categories H315 Skin Irrit. 2 H319 Eye Irrit. 2 H411 Aquatic Chronic 2 180 mL MW1 GHS02 WARNING Hazard classes/categories H226 Flam. Liq. 3 50 mL MW2 Do not need labelling as hazardous - No hazard class 250 mL MX GHS02 GHS07 GHS08 DANGER Hazard classes/categories H225 Flam. Liq. 2 H319 Eye Irrit. 2 H335 STOT SE 3 H351 Carc. 2 30 mL RNase-free H 2 O Do not need labelling as hazardous - No hazard class 200 U, Size C, rDNase GHS08 DANGER Hazard classes/categories H334 Resp. Sens. 1 - 125 mL MDB GHS02 125 mL ML GHS07 H412 Harmful to aquatic life with long lasting effects. 100 mL MP GHS07 GHS09 180 mL MW1 GHS02 H226 Flammable liquid and vapour. P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. 50 mL MW2 Do not need labelling as hazardous - 250 mL MX GHS02 GHS07 GHS08 DANGER H225, H319, H335, H351 Highly flammable liquid and vapour. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing cancer. P201, P210, P261sh, P280sh, P403+233 Obtain special instructions before use. Keep away from heat/sparks/open flames/hot surfaces. No smoking. Avoid breathing dust/vapours. Wear protective gloves/eye protection. Store in a well-ventilated place. Keep container tightly closed. 30 mL RNase-free H 2 O Do not need labelling as hazardous - 200 U, Size C, rDNase GHS08 DANGER H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. P261sh, P342+311 Avoid breathing dust/vapours. If experiencing respiratory symptoms: Call a POISON CENTER/doctor.

2.1 Classification of the substance or mixture

30 mL Buffer for rDNase Do not need labelling as hazardous

2.2 Label elements

According CLP directive inner packages must be only labelled with GHS symbol(s) and product identificator(s) (EU 1272/2008 Annex I - 1.5.1.2). Harmful chemicals/mixtures with signal word: WARNING and highly flammable chemicals/mixtures must not be labelled with H and P phrases until 125 mL (EU 1272/2008 Annex I - 1.5.2). This labelling exemption is NOT valid for sensibilizing substances. 30 mL Buffer for rDNase Do not need labelling as hazardous

2.3 Other hazards

Possible hazards from physicochemical properties In the case of pH values are less than 5 or higher than 9 then it is irritant. Flammable properties. Vapour forms explosive mixtures with air. The property H314 "Causes severe skin burns and eye damage." of some salts is not applicable, because the mixture is buffered to pH >3-4 (see GHS Directive 1272/2008/EC Annex I, chapter 3.2.3.1.2.). For guanidine thiocyanate CAS 593-84-0: The properties H314, H332 "Causes severe skin burns and eye damage. Harmful if inhaled." are not relevant, because the mixture solution is buffered to pH 4-9 (see GHS Directive 1272/2008/EC Annex I, chapter 3.2.3.1.2.). --- Information pertaining to particular risks to human and possible symptoms Cause after oral intake, inhalation of vapours/dust, impairments of health when ingested in small quantities. Kit contains small amounts of enzymes: May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing cancer. - Information pertaining to particular risks to the environment Harmful to aquatic life with long lasting effects. Avoid contact of substance/mixture to environment.

PBT Substances

not applicable

vPvB Substances

not applicable

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