Quinine Sulfate Capsules USP

SECTION 2: Hazards identification

Fire and Explosion Expected to be non-combustible. Health Quinine sulfate is contraindicated in patients with the following:  Prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum malaria.  Glucose-6-phosphate dehydrogenase (G6PD) deficiency.  Hemolysis can occur in patients with G6PD deficiency receiving quinine.  Known hypersensitivity reactions to quinine.  These include, but are not limited to, the following.  Thrombocytopenia.  Idiopathic thrombocytopenia purpura (ITP) and Thrombotic thrombocytopenic purpura (TTP).  Hemolytic uremic syndrome (HUS).  Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia).  Known hypersensitivity to mefloquine or quinidine: cross- sensitivity to quinine has been documented.  Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness.  Optic neuritis. Quinine may exacerbate active optic neuritis.

Environmental hazards

No information is available about the potential of this product to produce adverse environmental effects.