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SECTION 2: Hazards identification

OSHA HCS 2012 https:/Aww.unifrax.com/M SD SAPPR. nsf/By+ Trade+ Name/4B62E969F 505C D7985256A11006D: CAAE?O0penDocument 114 (a) Classification of the chemical in accordance with paragraph (d) of

Signal word

Warning

Hazard statements

Suspected of causing cancer by inhalation.

Precautionary statements

Do not handle until all safety instructions have been read and understood. Use respiratory protection as required; see section 8 of the Safety Data Sheet. If concerned about exposure, get medical advice. Store in a manner to minimize airborne dust. Dispose of waste in accordance with local, state and federal regulations.

Supplemental label elements

May cause temporary mechanical irritation to exposed eyes, skin or respiratory tract. Minimize exposure to airborne dust. (c) Describe any hazards not otherwise classified that have been identified during the classification process Mild mechanical irritation to skin, eyes and upper respiratory system may result from exposure. These effects are usually temporary. (@ Mixture rule https:/Awww.unifraxconYMSDSAPPR. nsf/By+ Trade+ Name/4B62E969F 505C D7985256A 1 1006D CAAE?0penDocument 2114 Not applicable. (a) Chemical and (b) Common Name {c) CAS Number % BY WEIGHT Refractories, Fibers, Aluminosilicate 142844-00-6 100 *Synonyms: RCF, ceramic fiber, Alumino Silicate Wool (ASW), synthetic vitreous fiber (SVF), man-made vitreous fiber (MMVF), man-made mineral fiber (MMMF), high temperature insulation wool (HTIW) (d) Impurities and stabilizing additives Not applicable. | _ 4. FIRST AID MEASURES (a) Description of necessary measures, subdivided according to the different routes of exposure, i.e., inhalation, skin and eye contact, and ingestion SKIN Handling of this material may generate mild mechanical temporary skin irritation. If this occurs, rinse affected areas with water and wash gently. Do not rub or scratch exposed skin. EYES In case of eye contact flush abundantly with water; have eye bath available. Do not rub eyes. NOSE AND THROAT If these become irritated move to a dust free area, drink water and blow nose. If symptoms persist, seek medical advice. (b) Most important symptoms/effects, acute and delayed Mild mechanical irritation to skin, eyes and upper respiratory system may result from exposure. These effects are usually temporary. (c) Indication of immediate medical attention and special treatment needed, if necessary NOTES TO PHYSICIANS Skin and respiratory effects are the result of temporary, mild mechanical irritation; fiber exposure does not result in allergic manifestations. ! 5. FIRE FIGHTING MEASURES (a) Suitable (and unsuitable) extinguishing media https:/Awww.unifraxcon/MSRSAPPR.nsf/Byt Trade+Name/4B62E969F 505C D7985256A 1 1006D CAAE?0penDocument 3/14 Use extinguishing agent suitable for surrounding combustible materials. (b) Specific hazards arising from the chemical (e.g., nature of any hazardous combustion products): Non-combustible products, class of reaction to fire is zero. Packaging and surrounding materials may be combustible. (c) Special protective equipment and precautions for fire-fighters NFPA Codes Flammability 0 Health 1 Reactivity 0 Special: 0 6. ACCIDENTAL RELEASE MEASURES (a) Personal precautions, protective equipment, and emergency procedures Minimize airborne dust. Compressed air or dry sweeping should not be used for cleaning. See Section 8 "Exposure Controls / Personal Protection" for exposure guidelines. (b) Methods and materials for containment and cleaning up Frequently clean the work area with vacuum or wet sweeping to minimize the accumulation of debris. Do not use compressed air for clean-up. EMPTY CONTAINERS Product packaging may contain residue. Do not reuse. 7. HANDLING AND STORAGE (a) Precautions for safe handling Handle fiber carefully to minimize airborne dust. Limit use of power tools unless in conjunction with local exhaust ventilation. Use hand tools whenever possible. (b) Conditions for safe storage, including any incompatibilities Store in a manner to minimize airborne dust. https:/Awww.unifraxcom/M SD SAPPR.nsf/By+ Trade+ Name/4B62E969F 505C D7985256A 1 1006D CAAE?0penD ocument 4114 8. EXPOSURE CONTROLS/PERSONAL PROTECTION (a)

Further information

¢ Concentrations based upon an eight-hour time weighted average (TWA) as determined by air samples collected and analyzed pursuant to NIOSH method 7400 (B) for airbome fibers. e The manufacturer recommends the use of a full-facepiece air purifying respirator equipped with an appropriate particulate filter cartridge during furnace tear-out events and the removal of used RCF to control exposures to airborne fiber and the potential presence of crystalline silica. 9. PHYSICAL AND CHEMICAL PROPERTIES (a) Appearance White, fibrous wool (j) Upper/lower flammability or Not applicable explosive limits (b) Odor Odorless (k) Vapor pressure Not applicable (c) Odor threshold Not applicable (I) Vapor density Not applicable (d) pH Not applicable (m) Relative density 2.50 — 2.75 (e) Melting point 1760° C (3200° F) (n) Solubility Insoluble (f) Initial boiling point Not applicable (0) Partition coefficient: n- Not applicable and boiling range octanol/water (g) Flash point Not applicable (p) Auto-ignition temperature Not applicable (h) Evaporation rate Not applicable (q) Decomposition temperature Not applicable (i) Flammability Not applicable (r) Viscosity Not applicable 40.STABILITYANDREACTIVITY i (a) Reactivity RCF is non-reactive. (b) Chemical stability As supplied RCF is stable and inert. (c) Possibility of hazardous reactions None (d) Conditions to avoid Please refer to handling and storage advice in Section 7 (e) Incompatible materials None (f) Hazardous decomposition None. products https:/Aww.unifrax convMSDSAPPR.nsf/By+ Trade+ Name/4B62E969F 505C D 7985256A 1 1096D CAAE?0penD ocument 6/14 11. TOXICOLOGICAL INFORMATION For more details on scientific publications referenced in this SDS see http://www.htiwcoalition.org/publications .htm| a) through (d TOXICOKINETICS, METABOLISM AND DISTRIBUTION Basic Toxicokinetics Exposure is predominantly by inhalation or ingestion. Man-made vitreous fibers of a similar size to RCF have not been shown to migrate from the lung and/or gut and do not become located in other organs of the body. Human Toxicological Data/Epidemiology Data In order to determine possible human health effects following RCF exposure, the University of Cincinnati has been conducting medical surveillance studies on RCF workers in the U.S.A; this epidemiological study has been ongoing for 25 years and medical surveillance of RCF workers continues. The Institute of Occupational Medicine (IOM) has conducted medical surveillance studies on RCF workers in European manufacturing facilities. Pulmonary morbidity studies among production workers in the U.S.A. and Europe have demonstrated an absence of interstitial fibrosis. In the European study a reduction of lung capacity among smokers has been identified, however, based on the latest results from a longitudinal study of workers in the U.S.A. with over 17-year follow-up, there has been no accelerated rate of loss of lung function (McKay et al. 2011). A statistically significant correlation between pleural plaques and cumulative RCF exposure was evidenced in the U.S.A. longitudinal study. The U.S.A. mortality study showed no excess mortality related to all deaths, all cancer, or malignancies or diseases of the respiratory system including mesothelioma (LeMasters et al. 2003). Information on Toxicological Effects e Acute toxicity: short term inhalation No data available: Short term tests have been undertaken to determine fiber (bio) solubility rather than toxicity; repeat dose inhalation tests have been undertaken to determine chronic toxicity and carcinogenicity. e Acute toxicity: oral No data available: Repeated dose studies have been carried out using gavage. No effect was found. e Skin corrosion/imitation Not a chemical irritant according to test method OECD no, 404. e Serious eye damage/initation Not possible to obtain acute toxicity information due to the morphology and chemical inertness of the substance. https:/Awww.unifraxconvM SD SAPPR.nsf/By+ Trade+Name/4B62E969F 505C D 7985256A 1 1006D CAAE?0penDocument 74 e Respiratory or skin sensitization No evidence from human epidemiological studies of any respiratory or skin sensitization potential. e Germ cell mutagenicity/genotoxicity Method: In vitro micronucleus test Species: Hamster (CHO) Dose: 1-35 mg/ml Routes of administration: In suspension Results: Negative e Carcinogenicity Method: Inhalation, multi-dose Species: Rat Dose: 3 mg/m®, 9 mg/m? and 16 mg/m? Routes of administration: Nose only inhalation Results: Fibrosis just reached significant levels at 16 and 9 mg/m= but not at 3 mg/m. None of the parenchymal tumor incidences were higher than the historical control values for this strain of animal. Method: Inhalation, single dose Species: Rat Dose: 30 mg/m3 Routes of administration: Nose only inhalation Results: Rats were exposed to a single concentration of 200 WHO fibers/ml specially prepared RCF for 24 months. High incidence of exposure-related pulmonary neoplasms (bronchoalveolar adenomas and carcinomas) was observed. A small number of mesotheliomas were observed in each of the fiber exposure groups (Mast et al 1995a). Method: Inhalation, single dose Species: Hamster Dose: 30 mg/m3 Routes of administration: Nose only inhalation Results: Hamsters were exposed to a single concentration of 260 WHO fibers/ml specially prepared RCF for 18 months and developed lung fibrosis, a significant number of pleural mesotheliomas (42/102) but no primary lung tumors (McConnell et al 1995). Method: Inhalation, single dose Species: Rat Dose RCF1 130 F/ml and 50 mg/m3 (25% of non fibrous particles) RCF1a: 125 F/ml and 26 mg/m3 (2% of non fibrous particles) Routes of administration: Nose only inhalation Results: Rats were exposed to RCF1 and RCF 1a for 3 weeks. The objective of the study was to compare lung retention and biological effects of the original RCF1 compared to RCF1a. The main difference of these 2 samples was the non-fibrous particle content of respectively 25% versus 2%. The post treatment observation was 12 months. Alveolar clearance was barely retarded after RCF1A exposure. After RCF1 exposure, however, a severe retardation of clearance was observed. (Bellmann et al 2001). After intraperitoneal injection of ceramic fibers into rats in three experiments (Smith et al 1987, Pott et al 1987, Davis et al 1984), mesotheliomas were found in the abdominal cavity in two studies, while the third report (Pott et al 1987) had incomplete histopathology. Only a few mesotheliomas were found in the abdominal cavity of hamsters after intraperitoneal injection in one experiment (Smith et al 1987). However, the ceramic fibers tested were of relatively large diameter. When rats and hamsters were exposed via intraperitoneal injection, tumor incidence was related to fiber length and dose (Smith et al 1987, Pott et al 1987, Miller et al 1999, Pott et al 1989). (From SCOEL publication (EU Scientific Committee on Occupational Exposure Limits) SCOEL/SUM/165, September 2011). https:/Aww.unifraxconYMSDSAPPR .nsfiBy+ Trade+ Name/4B62E969F 505C D7985253A 1 1006D CAAE?0penDocument 8/14 e Reproductive toxicity Method: Gavage Species: Rat Dose: 250mg/kg/day Routes of administration: Oral Results: No effects were seen in an OECD 421 screening study. There are no reports of any reproductive toxic effects of mineral fibers. Exposure to these fibers is via inhalation and effects seen are in the lung. Clearance of fibers is via the gut and the feces, so exposure of the reproductive organs is extremely unlikely. e STOT-Single exposure Not applicable e STOT-Repeated exposure Not applicable e Aspiration hazard Not applicable See the following review publications fora summary and discussion: Interpretation of these animal experiments is complex and there is not complete agreement amongst scientists internationally. A summary of the evidence relating to RCF carcinogenicity in vivo can be found in SCOEL/SUM/165 and in Utell and Maxim 2010.