TRIZOL REAGENT

Hazard statements (CLP)

H302, H312, H314, H332, H335, H341, H373, H412

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

Classification According to Directive 67/548/EEC or 1999/45/EC: In accordance with local and national regulations Complies Regulation (EC) No 1272/2008 Classification according to Directive 67/548/EEC or 1999/45/EC

Signal word

Danger

Health hazards

Acute oral toxicity Category 4 Acute dermal toxicity Category 4 Acute Inhalation Toxicity - Vapours Category 4 Skin corrosion/irritation Category 1 B Serious eye damage/eye irritation Category 1 Specific target organ systemic toxicity (single exposure) Category 3 Specific target organ systemic toxicity (repeated exposure) Category 2 Mutagenicity Mutagenic category 2

Physical hazards

Not Hazardous

Hazard statements

H314 - Causes severe skin burns and eye damage H341 - Suspected of causing genetic defects H373 - May cause damage to organs through prolonged or repeated exposure H412 - Harmful to aquatic life with long lasting effects H302 - Harmful if swallowed H312 - Harmful in contact with skin H332 - Harmful if inhaled H335 - May cause respiratory irritation

Precautionary statements

P301 + P312 - IF SWALLOWED: Call a POISON CENTRE or doctor/physician if you feel unwell P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTRE or doctor/physician P308 + P313 - IF exposed or concerned: Get medical advice/attention P273 - Avoid release to the environment P280 - Wear protective gloves/protective clothing/eye protection/face protection European Union

R-phrase(s)

R34 - Causes burns R68 - Possible risk of irreversible effects R48 - Danger of serious damage to health by prolonged exposure R41 - Risk of serious damage to eyes R37 - Irritating to respiratory system R52 - Harmful to aquatic organisms R53 - May cause long-term adverse effects in the aquatic environment R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed

S-phrase(s)

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S28 - After contact with skin, wash immediately with plenty of soap and water S45 - In case of accident or if you feel unwell, seek medical advice immediately S61 - Avoid release to the environment. Refer to special instructions/Safety data sheets S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Potential health effects

eyes Causes burns. Risk of serious damage to eyes. Corrosive to the eyes and may cause severe damage including blindness. Skin Causes burns. Possible risk of irreversible effects. Harmful in contact with skin. Irritating to skin and mucous membranes. Inhalation Harmful by inhalation. Ingestion Harmful if swallowed. Ingestion causes burns of the upper digestive and respiratory tracts. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea. Specific effects Carcinogenic effects Phenol has been classified by the International Agency for Research on Cancer (IARC) as not classifiable as to carcinogenicity to humans (Group 3). Mutagenic effects Not applicable Reproductive toxicity Not applicable Sensitisation Not applicable Target Organ Effects Skin Lungs Liver spleen Kidney