TRYPSIN 0.25% EDTA

Signal word

DANGER

Health hazards

Respiratory sensitization Category 1

Physical hazards

Not Hazardous

Environmental hazards

Not Hazardous

Hazard statements

H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled

Prevention

P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P284 - In case of inadequate ventilation wear respiratory protection

Response

P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing P342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician

Storage

Not Applicable

Disposal

P501 - Dispose of contents/ container to an approved waste disposal plant

2.3 Other hazards

Not Applicable HMIS Health 4 Flammability 0 Reactivity 0 Chemical Name CAS No. Common name EC No. Weight-% Trypsin 9002-07-7 Not applicable 232-650-8 0.1-1.0 We recommend handling all chemicals with caution. Description of first aid measures Skin contact Rinse skin with water. Immediate medical attention is not required. Eye contact Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Ingestion Never give anything by mouth to an unconscious person. Do not induce vomiting without medical advice. Call a physician or poison control center immediately. Inhalation Remove to fresh air. If not breathing, give artificial respiration. Call a physician or poison control center immediately. Notes to Physician Treat symptomatically. Most important symptoms and effects, both acute and delayed H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled Indication of any immediate medical attention and special treatment needed IF INHALED: Remove person to fresh air and keep comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Extinguishing media Suitable extinguishing media Water spray. Carbon dioxide (CO2). Foam. Dry chemical. Unsuitable extinguishing media No information available. Special hazards arising from the substance or mixture Not known Advice for firefighters Standard procedure for chemical fires. Personal precautions, protective equipment and emergency procedures Ensure adequate ventilation Always wear recommended Personal Protective Equipment Use personal protection equipment See section 8 for more information Environmental precautions Avoid release to the environment. Methods and material for containment and cleaning up Soak up with inert absorbent material. Reference to other sections See section 8 for more information. Precautions for safe handling Always wear recommended Personal Protective Equipment. Do not get in eyes, on skin, or on clothing. Do not ingest. If during normal use the material presents a respiratory hazard, use only with adequate ventilation or wear appropriate respirator. See section 8 for more information. Conditions for safe storage, including any incompatibilities Keep in a dry, cool and well-ventilated place. Keep in properly labeled containers. Store in accordance with local regulations. Specific end use(s) For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. Control parameters Chemical Name

Further information

Information with regard to physical hazard classes No information available Other safety characteristics No information available Reactivity None known. Chemical stability Stable under normal conditions. Possibility of hazardous Hazardous reaction has not been reported. reactions Conditions to avoid None under normal processing. Incompatible materials No dangerous reaction known under conditions of normal use. Hazardous decomposition None under normal use conditions. products Information on toxicological effects Chemical Name Oral LD50 Dermal LD50 Inhalation LC50 Trypsin > 5 g/kg (Rat) No data available Principal Routes of Exposure Acute toxicity Data are conclusive but insufficient for classification. Skin corrosion/irritation Data are conclusive but insufficient for classification Serious eye damage/irritationData are conclusive but insufficient for classification Respiratory or skin May cause sensitization by inhalation sensitization Specific target organ toxicity Data are conclusive but insufficient for classification Carcinogenicity Data are conclusive but insufficient for classification Germ cell mutagenicity Data are conclusive but insufficient for classification Reproductive toxicity Data are conclusive but insufficient for classification Aspiration hazard Data are conclusive but insufficient for classification Toxicity The environmental impact of this product has not been fully investigated. Chemical Name Toxicity to algae Toxicity to daphnia Toxicity to fish Microtox Data log Pow and other aquatic invertebrates Trypsin No data available Mobility in soil No information available. Persistence and degradability No information available. Bioaccumulative potential No information available. Results of PBT and vPvB assessment No information available. Other adverse effects No information available. Waste treatment methods The generation of waste should be avoided or minimized wherever possible. Empty containers or liners may retain some product residues. This material and its container must be disposed of in according to approved disposal technique. Disposal of this product, its solutions or of any by-products, shall comply with the requirements of all applicable local, regional or national/federal regulations. IATA / ADR / DOT-US / IMDG Not classified as dangerous in the meaning of transport regulations UN number or ID number Not Applicable UN proper shipping name Not Applicable Transport hazard class(es) Not Applicable Packing group Not Applicable Environmental hazards Not Applicable Special precautions for user Not Applicable Maritime transport in bulk according to IMO instruments Not Applicable. Component US TSCA Trypsin Listed 9002-07-7 ( 0.1-1.0 ) US Federal Regulations SARA 313 This product is not regulated by SARA. Clean Air Act, Section 112 Hazardous Air Pollutants (HAPs) (see 40 CFR 61) This product does not contain HAPs US State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. WHMIS Hazard Class D2A - Very toxic materials This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the SDS contains all the information required by the CPR. National Regulations - Brazil Chemical Name CAS No. Brazil - National Agency Brazil - National List of for Sanitary Surveillance Carcinogen Agents to (ANVISA) Humans (LINACH) Trypsin 9002-07-7 Not Listed Reason for revision SDS sections updated. Revision number 9 Revision date 31-Aug-2023 For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. References Abbreviations and acronyms TWA - Time-Weighted Average OELs - Occupational Exposure Limits STEL - Short Term Exposure Limit DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List KECL - Korean Existing and Evaluated Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances NZIoC - New Zealand Inventory of Chemicals EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances TSCA - United States Toxic Substances Control Act Section 8(b) Inventory CEPA - Canadian Environmental Protection Act EPA - Environmental Protection Agency OSHA - Occupational Safety and Health Administration of the US Department of Labor IATA - International Air Transport Association DOT - Department of Transportation IMDG - International Maritime Dangerous Goods ACGIH - American Conference of Governmental Industrial Hygienists NIOSH - National Institute for Occupational Safety and Health AIHA - American Industrial Hygiene Association HMIS - Department of Defense Hazardous Materials Information System NTP - National Toxicology Program IARC - International Agency for Research on Cancer "The above information was acquired by diligent search and/or investigation and the recommendations are based on prudent application of professional judgment. The information shall not be taken as being all inclusive and is to be used only as a guide. All materials and mixtures may present unknown hazards and should be used with caution. Since the Company cannot control the actual methods, volumes, or conditions of use, the Company shall not be held liable for any damages or losses resulting from the handling or from contact with the product as described herein. THE INFORMATION IN THIS SDS DOES NOT CONSTITUTE A WARRANTY, EXPRESSED OR IMPLIED,INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE" End of Safety Data Sheet