Protein BR Assay Reagent

Hazard statements (CLP)

H225, H302, H311, H319, H332

Code

Statements

H225

Highly Flammable liquid and vapour

Signal word

DANGER Hazard pictograms

Health hazards

Acute oral toxicity Category 4 Acute dermal toxicity Category 3 Acute inhalation toxicity - vapor Category 4 Serious eye damage/eye irritation Category 2

Physical hazards

Flammable liquids GHS Physical Hazard Category Number Category 2

Environmental hazards

Not Hazardous Hazard Statements H225 - Highly flammable liquid and vapor H302 - Harmful if swallowed H311 - Toxic in contact with skin H319 - Causes serious eye irritation H332 - Harmful if inhaled

Prevention

P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking P264 - Wash hands thoroughly after handling P280 - Wear protective gloves/protective clothing/eye protection/face protection P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P270 - Do not eat, drink or smoke when using this product

Response

P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing

Storage

P403 + P235 - Store in a well-ventilated place. Keep cool

Disposal

P501 - Dispose of contents/ container to an approved waste disposal plant

2.3 Other hazards

Not Applicable HMIS Health 4 Flammability 3 Reactivity 0 S E C T I O N 3: C o m p o sitio n/infor m a tio n o n in gr e di e n t s Chemical Name CAS No. Common name EINECS-No Weight-% Acetonitrile 75-05-8 Not applicable 200-835-2 90-100 We recommend handling all chemicals with caution. S E C T I O N 4: F irs t a id m e a s ur e s Description of first aid measures Skin contact Wash off immediately with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Immediate medical attention is required. Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Ingestion Never give anything by mouth to an unconscious person. Do not induce vomiting without medical advice. Get medical attention if symptoms occur. Inhalation Remove to fresh air. If not breathing, give artificial respiration. If symptoms persist, call a physician. Notes to Physician Treat symptomatically. Most important symptoms and effects, both acute and delayed H225 - Highly flammable liquid and vapor H302 - Harmful if swallowed H311 - Toxic in contact with skin H319 - Causes serious eye irritation H332 - Harmful if inhaled Indication of any immediate medical attention and special treatment needed IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. S E C T I O N 5: F ir e fig h tin g m e a s ur e s Extinguishing media Suitable extinguishing media Water spray. Carbon dioxide (CO2). Foam. Dry chemical. Unsuitable extinguishing media No information available. Special hazards arising from the substance or mixture No data Advice for firefighters Wear self-contained breathing apparatus and protective suit. S E C T I O N 6: A c c id e n t a l r e l e a s e m e a s ur e s Personal precautions, protective equipment and emergency procedures Ensure adequate ventilation Avoid contact with skin, eyes or clothing Use personal protection equipment See section 8 for more information Environmental precautions No special environmental precautions required. Methods and material for containment and cleaning up Soak up with inert absorbent material. Reference to other sections See section 8 for more information. S E C T I O N 7: H a n dlin g a n d s t or a g e Precautions for safe handling Always wear recommended Personal Protective Equipment. See section 8 for more information. Do not get in eyes, on skin, or on clothing. Do not ingest. If during normal use the material presents a respiratory hazard, use only with adequate ventilation or wear appropriate respirator. Conditions for safe storage, including any incompatibilities Keep in a dry, cool and well-ventilated place. Keep in properly labeled containers. Store in accordance with local regulations. Specific end use(s) For research use only. S E C T I O N 8: E x p o s ur e c o n trols/p e rs o n a l pro t e c tio n Control parameters Chemical Name

Further information

Information with regard to physical hazard classes No information available Other safety characteristics No information available S E C T I O N 1 0: S t a bilit y a n d r e a c tivit y Reactivity None known. Chemical stability Stable under normal conditions. Possibility of hazardous Hazardous reaction has not been reported. reactions Conditions to avoid No information available. Incompatible materials No dangerous reaction known under conditions of normal use. Hazardous decomposition No known hazardous decomposition products. products S E C T I O N 1 1: T o x i c olo gi c a l infor m a tio n Information on toxicological effects Chemical Name Oral LD50 Dermal LD50 Inhalation LC50 Acetonitrile = 160 mg/kg (Rat) >2000 µL/kg (Rabbit) 8 h 7551 ppm (Rat) Principal Routes of Exposure Acute toxicity Harmful if swallowed. Toxic in contact with skin. Harmful if inhaled. Skin corrosion/irritation Irritating to eyes Serious eye damage/irritationData are conclusive but insufficient for classification Respiratory or skin Data are conclusive but insufficient for classification sensitization Specific target organ toxicity Data are conclusive but insufficient for classification (STOT) – single exposure Specific target organ toxicity Data are conclusive but insufficient for classification (STOT) – repeated exposure Carcinogenicity Data are conclusive but insufficient for classification Germ cell mutagenicity Data are conclusive but insufficient for classification Reproductive toxicity Data are conclusive but insufficient for classification Aspiration hazard Data are conclusive but insufficient for classification S E C T I O N 1 2: E c olo gi c a l infor m a tio n Toxicity The environmental impact of this product has not been fully investigated. Chemical Name Toxicity to algae Toxicity to daphnia Toxicity to fish Microtox Data log Pow and other aquatic invertebrates Acetonitrile No data available logPow-0.34 Mobility in soil No information available. Persistence and degradability No information available. Bioaccumulative potential No information available. Results of PBT and vPvB assessment This mixture does not contain any substances that are assessed to be a PBT or a vPvB. Other adverse effects No information available. S E C T I O N 1 3: Dis p o s a l c o n sid e r a tio n s Waste treatment methods The generation of waste should be avoided or minimized wherever possible. Empty containers or liners may retain some product residues. This material and its container must be disposed of in according to approved disposal technique. Disposal of this product, its solutions or of any by-products, shall comply with the requirements of all applicable local, regional or national/federal regulations. Do not dispose of waste into sewer. S E C T I O N 1 4: T r a n s p ort infor m a tio n IATA / ADR / DOT-US / IMDG Classified as dangerous in the meaning of transport regulations UN number or ID number UN1648 UN proper shipping name Acetonitrile Solution Transport hazard class(es) 3 Packing group ll Environmental hazards Not Hazardous Special precautions for user Not Applicable Maritime transport in bulk according to IMO instruments Not Applicable. S E C T I O N 1 5: R e g ul a t ory infor m a tio n Component US TSCA Acetonitrile Listed 75-05-8 ( 90-100 ) US Federal Regulations SARA 313 This product contains the following toxic chemical(s) subject to the notification requirements of section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986. This law requires certain manufacturers to report on annual emissions of specified chemicals and chemical categories. Please note that if you repackage, or otherwise redistribute, this product to industrial customers, a notice similar to this one should be sent to those customers. Chemical Name CAS No. Weight-% SARA 313 - Threshold Values Acetonitrile 75-05-8 90-100 1.0 Clean Air Act, Section 112 Hazardous Air Pollutants (HAPs) (see 40 CFR 61) This product contains the following HAPs Component CAS No. Weight-% HAPS data Acetonitrile 75-05-8 90-100 Present 75-05-8 ( 90-100 ) US State Regulations Chemical Name Massachusetts - RTK New Jersey - RTK Pennsylvania - RTK (Right-to-Know) Acetonitrile Listed California Proposition 65 This product does not contain any Proposition 65 chemicals. WHMIS Hazard Class B2 - Flammable liquid D2B - Toxic materials This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the SDS contains all the information required by the CPR. National Regulations - Brazil Chemical Name CAS No. Brazil - National Agency Brazil - National List of for Sanitary Surveillance Carcinogen Agents to (ANVISA) Humans (LINACH) Acetonitrile 75-05-8 Not Listed S E C T I O N 1 6: O t h e r infor m a tio n Reason for revision SDS sections updated. Revision number 2 Revision date 25-Jan-2021 For research use only. Not for use in diagnostic procedures. References • ECHA: http://echa.europa.eu/ • TOXNET: http://toxnet.nlm.nih.gov/ • eChemPortal: http://www.echemportal.org/ • LOLI database: https://www.chemadvisor.com/loli-database Abbreviations and acronyms TWA - Time-Weighted Average OELs - Occupational Exposure Limits STEL - Short Term Exposure Limit DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List KECL - Korean Existing and Evaluated Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances NZIoC - New Zealand Inventory of Chemicals EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances TSCA - United States Toxic Substances Control Act Section 8(b) Inventory CEPA - Canadian Environmental Protection Act EPA - Environmental Protection Agency OSHA - Occupational Safety and Health Administration of the US Department of Labor IATA - International Air Transport Association DOT - Department of Transportation IMDG - International Maritime Dangerous Goods ACGIH - American Conference of Governmental Industrial Hygienists NIOSH - National Institute for Occupational Safety and Health AIHA - American Industrial Hygiene Association HMIS - Department of Defense Hazardous Materials Information System NTP - National Toxicology Program IARC - International Agency for Research on Cancer "The above information was acquired by diligent search and/or investigation and the recommendations are based on prudent application of professional judgment. The information shall not be taken as being all inclusive and is to be used only as a guide. All materials and mixtures may present unknown hazards and should be used with caution. Since the Company cannot control the actual methods, volumes, or conditions of use, the Company shall not be held liable for any damages or losses resulting from the handling or from contact with the product as described herein. THE INFORMATION IN THIS SDS DOES NOT CONSTITUTE A WARRANTY, EXPRESSED OR IMPLIED,INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE" End of Safety Data Sheet Safety Data Sheet ___________________________________________________________________________________________________________________ S E C T I O N 1: Id e n tifi c a tio n of t h e s u b s t a n c e/m i x t ur e a n d of t h e c o m p a n y/u n d e rt a k in g Identification of the substance or mixture Product code 1863698 Product name Standard 2, 10mg/mL BSA Company/undertaking identification Life Technologies Corporation Life Technologies 5781 Van Allen Way 5250 Mainway Drive PO Box 6482 Burlington, ONT Carlsbad, CA 92008 CANADA L7L 6A4 +1 760 603 7200 800/263-6236 Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 1.815.968.0747 or 1.800.874.3723 24 hour Emergency Response for Hazardous Materials Within the USA + Canada: 1-800-424-9300 and [or Dangerous Goods] Incident. Spill, Leak, Fire, 1-703-527-3887 Exposure, or Accident. Call CHEMTREC Outside the USA + Canada: 1-703-741-5970 Country Specific Emergency Number (if available): For research use only. Not for use in diagnostic procedures S E C T I O N 2: H a z a rd s id e n tifi c a tio n GHS Classification Signal Word None Hazard pictograms None Health hazards Not Hazardous Physical hazards Not Hazardous Environmental hazards Not Hazardous Hazard Statements Not Applicable Precautionary Statements Prevention Not Applicable Response Not Applicable Storage Not Applicable Disposal Not Applicable Other hazards Not Applicable HMIS Health 0 Flammability 0 Reactivity 0 S E C T I O N 3: C o m p o sitio n/infor m a tio n o n in gr e di e n t s The product contains no substances which at their given concentration, are considered to be hazardous to health. We recommend handling all chemicals with caution. S E C T I O N 4: F irs t a id m e a s ur e s

2.1 Classification of the substance or mixture

Signal Word DANGER Hazard pictograms Health hazards Acute oral toxicity Category 4 Acute dermal toxicity Category 3 Acute inhalation toxicity - vapor Category 4 Serious eye damage/eye irritation Category 2 Physical hazards GHS Physical Hazard Flammable liquids GHS Physical Hazard Category Number Category 2 Environmental hazards Not Hazardous Hazard Statements H225 - Highly flammable liquid and vapor H302 - Harmful if swallowed H311 - Toxic in contact with skin H319 - Causes serious eye irritation H332 - Harmful if inhaled