4-(Methylamino)phenol Sulfate Solution

SECTION 2: Hazards identification

Emergency Overview Appearance: Clear, colorless to lt. tan solution Warning! Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May cause allergic skin reaction. May cause blood abnormalities. Contact with acids liberates toxic gas. Target Organs: Blood, kidneys, spleen, skin, respiratory system

Potential health effects

Eye: Causes eye irritation. Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be harmful if absorbed through the skin. Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause blood abnormalities. Sulfite compounds may cause a severe allergic reaction in sensitive - 1 - individuals and some asthmatics. Groups of 5 male rats were fed 1.0 or 0.1% of p- methylaminophenol sulfate in the diet for 11 days. Abnormalities observed in the high-dose group included a slight brown discoloration of the tail, decreased hemoglobin & hematocrit, changes in red blood cell morphology, & an increase in absolute & relative spleen weights. Gross & histopathologic changes included enlarged spleens & splenic congestion. No treatment-related effects were observed at the low-dose level. (Eastman Kodak) Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. May cause respiratory sensitization. Chronic: Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Groups of 20 male & 20 female rats were administered 61-66 doses (gavage) of 30, 100 or 300 mg/kg of Elon (p- methylaminophenol sulfate) over a period of 91-94 days. Except for brown urine & decreased activity, death occurred without prior signs of toxicity in 20 animals at the high dose-level & 7 animals in the intermediate dose group. Deaths were associated with necrosis of the renal tubular epithelial cells. Abnormalities in the high & intermediate dose groups included degeneration of hemoglobin in circulating erythrocytes, hemolytic anemia, discolored & enlarged spleens, & hemoglobinuric nephrosis. Minor kidney, spleen and red blood cell effects were also observed in some of the low-dose animals. (Eastman Kodak)