ARSENIC TRIOXIDE

Health hazards

Information OSHA Effects of Overexposure Skin Contact: Information Effects of Overexposure Skin Contact: No irritation is likely upon brief contact. May be irritating after prolonged or repeated contact. Prolonged or repeated contact may cause dermatitis. Eye Contact: May irritate or burn the eyes. Ingestion: Harmful or fatal if swallowed. Symptoms include throat constriction, abdominal pain, vomiting and watery diarrhea. Blood may appear in vomit or stools. Onset of symptoms may be delayed by 1/2 to 4 hours. If amount ingested is sufficiently high, shock may develop due to severe fluid loss, and death may follow within 24 hours. If acute symptoms are survived they may be followed by inflammation of the skin, nerve degeneration, pain, sensory disturbances and impaired or lost reflexes. Inhalation: Harmful or fatal if inhaled Acute arsenic poisoning from inhalation is rare, however, it can occur. Symptoms include cough, chest pain, dyspnea, headache and extreme general weakness followed by the symptoms outlined under ingestion. Storage and Handling Precautions Store in a cool, dry well-ventilated area or cabinet dedicated to toxic storage. Isolate away from incompatible materials. Keep containers well closed. Transportation Information Regulated Material domestic ground transportation (reference: CFR Title 49, Transportation) Proper Shipping Name: Arsenic trioxide UN or NA Identification number: UN1561 Hazard Class and Label: 6.1 Toxic Packing Group: II Subsidiary Risk and Label: Regulated Material via Air Transportation (reference: ICAO Technical Instructions for the Safe Transport of Dangerous Goods by Air) Proper Shipping Name: Arsenic trioxide UN Identification Number: UN1561 Hazard Class and Label: 6.1 Toxic Packing Group: II Subsidiary Risk and Label: Packing Instruction Max net qty per package Passenger Aircraft: 613/Y613 25/1 kg Cargo Aircraft: 615 100 kg Regulatory Information TSCA CERCLA SARA EHS SARA 313 Toxic Release Component Inventory RQ TPQ de minimus Arsenic trioxide 1 lbs 100 lbs 0.1 lbs SARA Hazard Categories: Acute Chronic Flammability Pressure Reactivity Arsenic trioxide Clean Air Act Categories: SOCMI HAP Volatile HAP Organic HAP Ozone Depleting Arsenic trioxide MSDS Revision History: 002 - Changed header phone number 003 - Format revisions; updated header phone number 004 - Updated Header Information NE = Not established, NA = Not applicable or Not available The information presented above is offered for informational purposes only. This MSDS, and the associated product, is intended for use only by technically qualified persons, and at their own discretion and risk. Since conditions and manner of use are outside the control of Integra Chemical Company, we make no warranties, either expressed or implied, and assume no liability in connection with any use of this information.

Potential chronic health

of Overexposure Chronic arsenic poisoning is characterized by loss of appetite, mild nausea, occasional vomiting, heaviness in the stomach and some diarrhea. This may be followed by inflammation of the mucous membranes, hoarseness and respiratory irritation. Prolonged exposure may perforate the nasal septum and cause skin sensitization and lesions. Exposure Limits: OSHA PEL TWA STEL Ceiling Arsenic trioxide (as As) 0.01 mg/m3 NE ACGIH TLV TWA STEL Ceiling Arsenic trioxide (as As) 0.2 mg/m3 NE Toxicity Data: Arsenic trioxide TDlo (oral, woman) 600 mg/kg LD50 (oral, man) 1.43 mg/kg LD50 (oral, rat) 15.1 mg/kg

Medical Conditions Generally Aggravated by Exposure

None Identified Target Organs: Bone marrow, respiratory system, skin. Reproductive Effects: None Identified Carcinogenicity: Exposure to arsenic compounds have been linked to lung cancer and possibly skin and liver cancers. Component NTP Listing IARC Listing OSHA Regulated Arsenic trioxide Group 1, Known Carcinogen Group 1, Known Human Carcinogen Emergency First Aid Procedures Emergency First Aid Procedures Skin Contact: Immediately remove contaminated clothing. Flush skin with water for at least 15 minutes. Seek immediate medical attention. Eye Contact: Flush with water for at least 15 minutes. Seek immediate medical attention. Inhalation: Remove victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult administer oxygen. Seek medical attention. Ingestion: If conscious, give victim large amounts of water. Seek medical attention. Additional First aid and Treatment Notes: No information available Reactivity Data Stability: Stable Hazardous Polymerization: Will Not Occur Incompatibles: Incompatible with strong oxidizers. Chlorine trifluoride; fluorine; hydrogen fluoride; sodium chlorate. Arsine gas can be generated by contact of acid, alkalies or water with arsenic compounds in the presence of an active metal (zinc, aluminum, magnesium, manganese, sodium, iron etc.). Decomposition Products: Sublimes when heated. Arsine gas on decomposition. Conditions to Avoid: Excessive heat. Spill and Disposal Procedures Spill and Leak Procedures: Wear self-contained breathing apparatus and full protective clothing. Carefully vacuum (vacuum must have a high efficiency filter system to prevent dust dispersion) the material into a clean, dry disposal container in a manner that minimizes dusting. Cover and save for proper disposal. Flush spill area with water.

Disposal

Procedures Dispose in accordance with all Local, State and Federal regulations. Protective Equipment Ventilation: Use general or local exhaust ventilation to meet TLV and PEL requirements. Respiratory Protection: If ventilation controls do not limt airborne concentrations below PEL and TLV values, an approved high-efficiency particulate respirator must be worn. Skin and Eye Protective Equipment: Safety goggles, protective clothing and gloves. Maintain an eyewash station and safety shower nearby. Storage and Handling Precautions

Storage

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