Substrate Bonder SB100

Principle Routes of Exposure

Skin Contact: Yes(Part A) Eye Contact: Yes (Part B) Ingestion: Yes (Part A) Inhalation: Yes (Part A) Emergency Overview: Off white, viscous liquid with a characteristic earthy, musty odour. Can probably burn if strongly heated. Can decompose at high temperatures forming toxic gases, such as nitrogen oxides and hydrogen cyanide. May polymerize if heated above 50 deg C. Reacts with water. Closed containers may develop pressure and rupture on prolonged exposure to heat or if contaminated with water. VERY TOXIC. Aerosol may be fatal if inhaled. May cause lung injury - effects may be delayed. SKIN IRRITANT. Causes severe skin irritation. Respiratory Sensitizer! May cause severe allergic respiratory reaction. Skin sensitizer! May cause severe allergic skin reaction.

Potential Acute Health Effects

Inhalation: This product contains materials that are low in volatility. Therefore, airborne exposures are unlikely to occur unless the product is heated or forms an aerosol or mist during use. Short-term exposure to isocyanates can cause resiratory and muscous membrane irritation. Symptoms incluse eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and latyngitis. Coughing with chest pain or tightness may also occur, frequently at night. These symptoms may occur during exposure or may be delayed by hours. Some people may become sensitized to this product. Skin Contact: This product is may cause severe irritation to skin. In general isocyanates can cause skin discolouration and hardenening of the skin after repeated exposures. Skin may becaome sensitized to this propduct. Eye Contact: Ingredients in Part B may cause severe eye irritation. Ingestion: There have been no reports of human ingestion of 4,4'-MDI. Animal studies indicate that the toxic effects of the ingestion of 4,4'-MDI are slight. Ingestion could result in irritation and corrosion of the mouth, throat, and digestive tract. Ingestion is not a typical route of occupational exposure.

Potential chronic health

Respiratory sensitization has developed in people working with MDI. The sensitization is usually caused by a very large exposure or by multiple exposures. Although varying periods of exposure (1 day to years) may elapse before sensitization occurs, it develops more often during the first few months of exposure. Sensitized individuals react to very low levels of MDI (as low as 0.0014 ppm) that have no effect on unsensitized people. At first, the symptoms may appear to be a cold or mild hay fever. However, severe asthmatic symptoms can develop and include wheezing, chest tightness, shortness of breath, difficulty breathing and/or coughing. Fever, chills, general feelings of discomfort, headache and fatigue can also occur. Symptoms may occur immediately upon exposure, within an hour or several hours after exposure or both and/or at night. Typically the asthma improves with removal from exposure (e.g. weekends and vacations) and returns, in some cases, in the form of an "acute attack", on renewed exposure. Sensitized people who continue to work with MDI may develop symptoms sooner after each exposure. The number and severity of symptoms may increase. Following removal from exposure, some workers may continue to have persistent respiratory problems such as asthmatic symptoms, bronchial problems and hypersensitivity to MDI. Others may recover fully and may gradually lose their sensitivity within several years. Integra Adhesives Inc., - 2 - Allergic contact dermatitis has developed from occupational contact with MDI. It has been proposed that a break-down (hydrolysis) product of MDI, 4,4'-methylene dianiline (MDA), is the real allergen rather than MDI. Following occupational contact with MDI, 3 of 4 people showed reaction to MDA as well as MDI, while one showed reaction to MDA only. IARC has concluded that ingredients in this product are not classifiable as to its carcinogenicity to humans.

Medical Conditions Generally Aggravated by Exposure

Pre-existing eye, skin, respiratory tract disorders may be aggravated by exposure. Previous sensitization to MDI will cause sensitization attacks.