452 Make-up Ink

Hazard statements (CLP)

H225, H319, H335

Code

Statements

H225

Highly Flammable liquid and vapour

SECTION 2: Hazards identification

According to Regulation (EC) No 1272/2008 [CLP Classification of the Substance or Mixture

Signal word

Danger

Hazard statements

H225 - Highly flammable liquid and vapor. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation.

Precautionary statements

P233 - Keep container tightly closed. P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P240 - Ground/bond container and receiving equipment. P241 - Use explosion-proof electrical/ventilating/lighting/.../ equipment. P243 - Take precautionary measures against static discharge. P242 - Use only non-sparking tools. P264 - Wash hands thoroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.

Response

P370+378 - In case of fire, use ... to extinguish. Revision: 12/11/2013 P303+361+353 - IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. P305+351+338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+313 - If eye irritation persists, get medical advice/attention. P309+311 - Call a POISON CENTER or doctor/physician if exposed or you feel unwell. P304+340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Storage

P403+235 - Store in cool/well-ventilated place. P501 - Dispose of contents/container to .... P405 - Store locked up. P403+233 - Store container tightly closed in well-ventilated place - if product is as volatile as to generate hazardous atmosphere.

Potential health effects

Prolonged or repeated skin contact may cause defatting and dermatitis. Chronic: May cause reproductive and fetal effects. Laboratory experiments have shown mutagenic effects. Animal studies have reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart damage. Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation may cause effects similar to those of acute inhalation. Matsushita et al. exposed human volunteers 6 hours/day for 6 days at 500 ppm acetone and found hematologic changes including significantly increased leukocyte and eosinophil counts and decreased neutrophil phagocytic activity. 2.3.1 Inhalation Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause narcotic effects in high concentration. Causes upper respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause motor incoordination and speech abnormalities. 2.3.2 Skin Contact Causes moderate skin irritation. May cause cyanosis of the extremities. May cause irritation with pain and stinging, especially if the skin is abraded. Isopropanol has a low potential to cause allergic skin reactions; however, rare cases of allergic contact dermatitis have been reported. Dermal absorption has been considered toxicologically insignificant. The cases of deep coma associated with skin contact are thought to be a consequence of gross isopropanol vapor inhalation in rooms with inadequate ventilation, rather than being attributable to percutaneous absorption of isopropanol per se. May be absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin. 2.3.3 Eye Contact Causes severe eye irritation. May cause painful sensitization to light. May cause chemical conjunctivitis and corneal damage. Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. May cause transient corneal injury. Vapors may cause eye irritation. 2.3.4 Ingestion May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. The probable oral lethal dose in humans is 240 ml (2696 mg/kg), but ingestion of only 20 ml (224 mg/kg) has, but in gestion of only 20 ml (224 mg/kg) has caused poisoning. May cause irritation of the digestive tract. Revision: 12/11/2013

2.1 Classification of the substance or mixture

2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]: Flammable Liquids, Category 2 Serious Eye Damage/Eye Irritation, Category 2A Specific Target Organ Toxicity (single exposure), Category 3