Peg8000 (

Hazard statements (CLP)

H302, H412

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

Classification of the substance or mixture

Signal word

Warning

Hazard statements

H302 Harmful if swallowed. H412 Harmful to aquatic life with long lasting effects.

Precautionary statements

P273 Avoid release to the environment. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.

Supplemental label elements

none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 3.1 Substances Synonyms threo-1,4-Dimercapto-2,3-butanediol Cleland’s reagent DTT Formula C4H10O2S2 Molecular weight 154,25 g/mol CAS-No. 3483-12-3 EC-No. 222-468-7 Component

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Long-term (chronic) aquatic hazard (Category 3), H412 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Warning Hazard statement(s) H302 Harmful if swallowed. H412 Harmful to aquatic life with long lasting effects. Precautionary statement(s) P273 Avoid release to the environment. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Supplemental Hazard none Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. SECTION 3: Composition/information on ingredients 3.1 Substances Synonyms : threo-1,4-Dimercapto-2,3-butanediol Cleland’s reagent DTT Formula : C4H10O2S2 Molecular weight : 154,25 g/mol CAS-No. : 3483-12-3 EC-No. : 222-468-7

Further information

No data available SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13. SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place. Store in cool place. Recommended storage temperature 2 - 8 °C 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection 8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: powder Colour: white b) Odour unpleasant c) Odour Threshold No data available d) pH 4,0 - 6 at 15,4 g/l at 25 °C e) Melting Melting point/range: 41 - 44 °C No point/freezing point f) Initial boiling point data available and boiling range g) Flash point 113 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, No data available gas) j) Upper/lower No data available flammability or explosive limits k) Vapour pressure No data available l) Vapour density No data available m) Relative density No data available n) Water solubility 15,4 g/l at 20 °C o) Partition coefficient: n- log Pow: 0,12 at 25 °C - Bioaccumulation is not expected., (Lit.)log octanol/water Pow: -0,5 at 25 °C - Bioaccumulation is not expected. p) Auto-ignition No data available temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability May decompose on exposure to moist air or water. Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Bases, Oxidizing agents, Reducing agents, Alkali metals 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5 Full text of H-Statements referred to under sections 2 and 3. H302 Harmful if swallowed. H412 Harmful to aquatic life with long lasting effects.

TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 400 mg/kg Remarks: (External MSDS) Skin corrosion/irritation No data available Serious eye damage/eye irritation No data available Respiratory or skin sensitisation No data available Germ cell mutagenicity No data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available

Aspiration hazard

No data available

Additional information

RTECS: EK1610000 Nausea, Headache, Vomiting, Central nervous system depression, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Liver - Irregularities - Based on Human Evidence

ECOLOGICAL INFORMATION

12.1 Toxicity No data available Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 27 mg/l - 48 h Remarks: and other aquatic (ECOTOX Database) invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other hazards

Harmful to aquatic life with long lasting effects. No data available SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information

UN Number

ADR/RID: - IMDG: - IATA: 3335 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Aviation regulated solid, n.o.s. ((R*,R*)-1,4-Dimercaptobutane-2,3-diol) 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: 9 14.4 Packaging group ADR/RID: - IMDG: - IATA: III

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture