Acetic acid (glacial) 100% anhydrous for analysis EMSURE

Health hazards

Information

TOXICOLOGICAL INFORMATION

Acute toxicity LC50 (inhalation, rat) 11.4 mg/l /4 h LD50 (dermal, rabbit) 1060 mg/kg; LD50 (oral, rat) 3310 mg/kg Specific symptoms in animal studies: Eye irritation test (rabbit): Burns. Skin irritation test (rabbit): Burns. Bacterial mutagenicity Salmonella typhimurium negative Bacterial mutagenicity Escherichia coli negative Bacterial mutagenicity Ames test negative Carcinogen Category: No evidence of carcinogenic properties. Mutagen Category: No evidence of mutagenic effects. Teratogen Category: No teratogenic effect in animal experiments. Strongly corrosive substance. After inhalation of vapours: Irritation symptoms in the respiratory tract. Inhalation may lead to the formation of oedemas in the respiratory tract. After skin contact: Burns. After eye contact: Burns. Risk of blindness! Risk of corneal clouding. After ingestion: Burns in oesophagus and stomach, gastric spasms, bloody vomiting, dyspnoea. Risk of perforation in the oesophagus and stomach. Pulmonary failure possible after aspiration of vomit. Cannot be excluded: Shock, cardiovascular failure, acidosis. Damage to kidneys. http://ecom.merck.com.au/msds/showmsds.aspx?product=1.00063 3/6 Product Code: 1.00063 (Acetic acid (glacial) 100% anhydrous for analysis EMSURE® ACS,ISO,Reag. Ph Eur) First Aid Information For advice, contact a doctor or Poisons Information Centre. Phone 13 1126. Eye contact: Hold eyes open, flood with water for at least 15 minutes and see a doctor. Inhalation: Remove from exposure, rest and keep warm. In severe cases, or if exposure has been great, OBTAIN MEDICAL ATTENTION. Skin contact: Drench the skin thoroughly with water. Remove contaminated clothing and wash before re-use. Unless contact has been slight, OBTAIN MEDICAL ATTENTION. Ingestion: Wash out mouth thoroughly with water and give plenty of water to drink. If swallowed, do NOT induce vomiting. OBTAIN MEDICAL ATTENTION. Contact a doctor or Poisons Information Centre. Phone 13 1126. First Aid Facilites: Safety shower. Eyewash facilities. Advice to Doctor: Treat symptomatically.

Precautionary statements

For Use NOHSC Australia Exposure Standards: TWA STEL Acetic acid glacial 10 ppm 15 ppm 25 mg/m3 37 mg/m3 Peak Limit: N/A Carcinogen Limit: N/A Protective Measures: Engineering Controls & As appropriate to quantity handled. Personal Protection: Respirator: Required when vapours/aerosols are generated. Ensure respirator is clean, well-fitting and in good working order. All respirators should comply with Australian Standard AS 1716 and be used in accordance with AS 1715. Ventilation: Fume cupboard, flameproof. Mechanical extraction sufficient to maintain the airborne concentration below the recommended exposure level. Gloves: Nitrile Eye Protection: Goggles or face-shield Other Precautions: Plastic apron, sleeves, boots - if handling large quantities http://ecom.merck.com.au/msds/showmsds.aspx?product=1.00063 4/6 Product Code: 1.00063 (Acetic acid (glacial) 100% anhydrous for analysis EMSURE® ACS,ISO,Reag. Ph Eur) Safe Handling Information:

Storage

Store in a warm place (above 20°C) to prevent freezing. Keep well closed and protected from direct sunlight and moisture. Handling: Avoid contact with liquid and inhalation of vapour/aerosols. Replace contaminated clothing and wash before re-use. Take precautions against static discharge. All electrical equipment must be flameproofed. Transport:

UN Number

2789 Dangerous Goods Class & Subsidiary Risk: 8 + 3 Packaging Group: II Other Names: ACETIC ACID, GLACIAL Spillage and Disposal: Shut off all sources of ignition. Wear appropriate protective clothing. Inform others to keep at a safe distance. Absorb on an inert absorbent, transfer to container and arrange removal by disposal company. Ventilate area to dispel residual vapour. For large spillages liquids should be contained with sand or earth and both liquids and solids transferred to salvage containers. Any residues should be treated as for small spillages. Render harmless: neutralize with diluted sodium hydroxide solution. Chemical residues are generally classified as special waste, and as such are covered by regulations, which vary according to location. We strongly recommend that you retain the services of a licensed Waste Disposal Company to dispose of your waste. Rinse out empty containers thoroughly before disposal or recycling. The containers recommended A, B, C etc allow for the consolidation of similar types of waste prior to professional disposal. Aqueous solutions of organic acids should be carefully neutralised with sodium hydrogen carbonate (Cat. No. 1.06323) or with sodium hydroxide (Cat. No. 1.06462). Before filling into container D, check the pH with pH universal indicator strips (Cat. No. 1.09535). Aromatic carboxylic acids should be precipitated with dilute hydrochloric acid and vacuum-filtered off. Precipitate container C; filtrate container D Fire and Explosion: Flammability: Flammable. Vapour/air mixture explosive. Suitable Extinguishing Media Suitable extinguishing media Water, CO2, foam, powder http://ecom.merck.com.au/msds/showmsds.aspx?product=1.00063 5/6 Product Code: 1.00063 (Acetic acid (glacial) 100% anhydrous for analysis EMSURE® ACS,ISO,Reag. Ph Eur) Other Information: Hazard Symbol: C Risk Codes: R10-35 Flammable. Causes severe burns. Safety Codes: S23B-26-45 Do not breathe vapour. In case of contact with eyes, rinse immediately with plenty of water and contact a doctor or Poisons Information Centre. In case of accident or if you feel unwell, contact a doctor or Poisons Information Centre immediately and show this container or label. Phone 13 1126. Ecological Information Biologic degradation Biodegradation 99 % /30 d (closed bottle test). Readily biodegradable. Behavior in environmental compartments Distribution log p(o/w) -0.17. No bioaccumulation is to be expected (log P(o/w <1). Passage from aqueous solution into the atmosphere is not to be expected. Ecotoxic effects: Biological effects: Harmful effect on aquatic organisms. Harmful effect due to pH shift. Caustic even in diluted form. Fish toxicity L.macrochirus LC50 75 mg/l /96 h. P.promelas LC50: 88 mg/l /96 h. Daphnia toxicity Daphnia magna EC50 47 mg/l /24 h Bacterial toxicity Photobacterium phosphoreum EC50 11 mg/l /15 min microtox test. Maximum permissible toxic concentration: Algeal toxicity Sc.quadricauda IC5 4000 mg/l /16 h Bacterial toxicity Ps.putida EC5 2850 mg/l /16 h neutral Protozoa E.sulcatum EC5 78 mg/l /72 h neutral Do not allow to enter waters, waste water, or soil! Key to Hazard Symbols: Xn=Harmful, Xi=Irritant, T=Toxic, T+=Very Toxic, C=Corrosive, F=Flammable, F+=Very Flammable, E=Explosive, N=Dangerous for the Environment, H=NOHSC undefined hazardous substance Contact Point: Operations Manager (03) 9728 5855 Monday through Friday, 8 00am to 5 00pm (EST) Manufacture's Advice: This MSDS summarises our best knowledge of the health and safety hazard information of the product and how to safely handle and use the product in the workplace.Each user should read this MSDS and consider the information in the context of how the product will be handled and used in the workplace including in conjunction with other product.If clarification of further information is needed to ensure that an appropriate risk assessment can be made, the user should contact this company.Our responsibility for products sold is subject to our standard terms and conditions, a copy of which is sent to our customers and is also available on request http://ecom.merck.com.au/msds/showmsds.aspx?product=1.00063