Fentanyl Citrate Injection, USP

Principle Routes of Exposure

Skin: Unlikely Inhalation: Unlikely 3. HAZARDS INFORMATION, continued ----------------------- Ingestion: Unlikely INGESTION RATING: Possibly highly toxic SKIN ABSORPTION RATING: N/D INHALATION RATING: N/D CORROSIVENESS RATING: N/D SKIN CONTACT RATING: N/D SKIN SENSITIZATION RATING: N/D EYE CONTACT RATING: N/D TARGET ORGANS: Central nervous system, lungs, fetus, eyes, cardiovascular system CARCINOGENICITY RATING NTP N/L IARC N/L OSHA N/L ACGIH: N/L None SIGNS AND SYMPTOMS: Clinically, overexposure can produce respiratory depression (breathing difficulties), reduced heart rate and muscle rigidity. Other adverse reactions include changes in blood pressure, dizziness, blurred vision, nausea, emesis, laryngospasm and perspiration. Opioid analgesics produce euphoria, miosis (constriction of pupils), reduced heart rate and bronchoconstriction. Overdose produces the same effects which if not treated can lead to cessation of breathing, unconsciousness and cardiac arrest. MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Data suggest conditions associated with impaired respiration, liver or kidney dysfunction, heart disease and concurrent use of central nervous system depressant drugs.