General Information
Revision date
2014-06-02
Product name
Methotrexate Injection, USP
Product Synonyms
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; 4-Amino-10-
CAS No.
59-05-2
Manufacturer Name
Hospira, Inc
Icons in SDS
Company Information
company name
Hospira, Inc
GHS Information
Signal word
Danger
Section 2
SECTION 2: Hazards identification
GHS Classification Emergency Overview Methotrexate Injection, USP is a solution containing methotrexate, a folic acid antagonist. Clinically, this product is used alone or with other agents to treat some types of cancers, to treat severe psoriasis, and rheumatoid arthritis. Methotrexate is a cytotoxic agent and in the workplace, should be considered a potential occupational reproductive hazard, and a potential carcinogen. Based on clinical use, possible target organs may include the bone marrow, gastrointestinal system, central nervous system, cardiovascular system, lungs, liver, kidney, skin, and gonads. U.S. OSHA GHS Classification
Hazard categories
Not Classified Toxic to Reproduction 1 Germ Cell Mutagenicity 2 STOT – RE 2
Signal word
Danger
Hazard statements
May damage fertility or the unborn child Suspected of causing genetic defects May cause damage to organs through prolonged or repeated exposure
Prevention
Obtain special instructions before use Do not handle until all safety precautions have been read and understood Wear protective gloves/protective clothing/eye protection/face protection Do not breathe vapor or spray Wash hands thoroughly after handling
Response
Get medical attention if you feel unwell. If exposed or concerned: Get medical advice/attention. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical attention. 1
