Lidocaine Hydrochloride Injection, USP, 1% & 2%

SECTION 2: Hazards identification

Active Ingredient Name Lidocaine Hydrochloride Chemical Formula C14H22N2O • HCl Component Approximate Percent by CAS Number RTECS Number Weight Lidocaine Hydrochloride ≤ 2.0% 73-78-9 AN7600000

Non Hazardous Components

include water and/or sodium chloride. Hazardous ingredients present at less than 1% may include sodium hydroxide and/or hydrochloric acid (used to adjust the pH). 3. HAZARD INFORMATION Emergency Overview Lidocaine Hydrochloride Injection, USP, 1% or 2%, contains lidocaine hydrochloride, an amide-type local anesthetic used as a local anesthetic for pain management. In the workplace, this product should be considered possibly irritating to the skin, eyes and respiratory tract. Possible target organs include the nervous system and cardiovascular system. Occupational Exposure Information on the absorption of this product via inhalation or skin contact is not available. Potential Published reports have indicated that similar local anesthetics have some potential to be absorbed through intact skin. Avoid liquid aerosol generation and skin contact. Signs and Symptoms Inadvertent contact with this product may cause irritation, followed by numbness. Ingestion may cause numbness of the tongue and anesthetic effects on the stomach. In clinical use, this product produces numbness when injected. In normal clinical use, adverse effects may include fever, headaches, agitation, tingling of extremities, general hypotension, bradycardia, dizziness, nausea, vomiting, anemia, back pain, post-operative pain and fetal distress. Systemic absorption can produce central nervous system (CNS) stimulation and/or CNS depression. CNS depression may progress to coma and cardio- respiratory arrest. Signs of cardiovascular toxicity may include changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance. Toxic blood levels may cause atrioventricular block, ventricular arrhythmias, cardiac arrest, and sometimes death. In addition, decreased cardiac output and arterial blood pressure may occur. Allergic-type reactions are rare but may occur due to sensitivity to the local anesthetic or to other formulation ingredients. These reactions are characterized by signs such as urticaria, pruritus, erythema, angioneurotic edema (including laryngeal 1 3. HAZARD INFORMATION: continued Signs and Symptoms: edema), tachycardia, sneezing nausea, vomiting, dizziness, syncope, excessive continued sweating, elevated temperature, and possibly, anaphylactic-like symptoms (including severe hypotension). Cross sensitivity with other amide-type local anesthetics has been reported. Medical Conditions Pre-existing hypersensitivity to lidocaine or related amide-type anesthetics. Pre- Aggravated by Exposure existing nervous system or cardiovascular ailments. Carcinogen Lists: IARC: Not listed NTP: Not listed OSHA: Not listed