Dacarbazine for Injection, USP

SECTION 2: Hazards identification

GHS Classification Emergency Overview Dacarbazine for Injection, USP, is a powder containing dacarbazine, an anti- neoplastic drug that acts as an alkylating agent after metabolic activation by the liver. Dacarbazine is used to treat some types of cancers. It is a cytotoxic agent, and should be considered potentially irritating to the eyes and respiratory tract, a potential occupational reproductive hazard, and a potential human carcinogen. Based on clinical use, possible target organs may include the bone marrow, gastrointestinal tract, central nervous system, liver, and skin. U.S. OSHA GHS Classification

Hazard categories

Not Classified Eye Damage/Irritation 2B Skin Corrosion/Irritation 2 Toxic to Reproduction 2 Germ Cell Mutagenicity 2 Carcinogenicity 2 STOT - RE 2

Signal word

Warning

Hazard statements

Causes eye irritation Causes skin irritation Suspected of damaging fertility or the unborn child Suspected of causing genetic defects Suspected of causing cancer May cause damage to organs through prolonged or repeated exposures 1 continued

Prevention

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wear protective gloves/protective clothing/eye protection/face protection. Do not breathe vapors/spray. Wash hands thoroughly after handling.

Response

If exposed or concerned: Get medical advice/attention. Get medical attention if you feel unwell. IF ON SKIN Wash with plenty of water. If skin irritation occurs Get medical advice/attention. Take off contaminated clothing and wash it before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical attention.