ThinPrep CytoLyt Solution A methanol based, buffered preservative solution used to support cells during transport

Hazard statements (CLP)

H226, H302, H312, H332, H370

Code

Statements

H226

Flammable liquid and vapour

SECTION 2: Hazards identification

GHS - Classification Dangerous substance or mixture according to the Globally Harmonized System (GHS) Acute toxicity - Oral Category 4 Acute toxicity - Dermal Category 4 Acute toxicity - Inhalation (Vapors) Category 4 STOT - single exposure Category 1 Flammable liquids Category 3 Label Elements Dangerous substance or mixture according to the Globally Harmonized System (GHS) Page 1/7 Language EN Review Date 08-May-2019 276

Signal word

Danger Hazard Statements H302 - Harmful if swallowed H312 - Harmful in contact with skin H332 - Harmful if inhaled H370 - Causes damage to organs H226 - Flammable liquid and vapor

Precautionary statements

P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking P280 - Wear protective gloves/protective clothing/eye protection/face protection P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P270 - Do not eat, drink or smoke when using this product P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish P403 + P235 - Store in a well-ventilated place. Keep cool P501 - Dispose of contents/container in accordance with local, regional, national, and international regulations as applicable

2.3 Other hazards

Not applicable

2.1 Classification of the substance or mixture

Dangerous substance or mixture according to the Globally Harmonized System (GHS). Acute toxicity - Oral Category 4 Acute toxicity - Dermal Category 4 Acute toxicity - Inhalation (Vapors) Category 4 STOT - single exposure Category 1 Flammable liquids Category 3 Label Elements Dangerous substance or mixture according to the Globally Harmonized System (GHS). Page 1/7 Language EN Review Date 08-May-2019 276 Signal word Danger Hazard Statements H302 - Harmful if swallowed H312 - Harmful in contact with skin H332 - Harmful if inhaled H370 - Causes damage to organs H226 - Flammable liquid and vapor Precautionary Statements P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking P280 - Wear protective gloves/protective clothing/eye protection/face protection P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P270 - Do not eat, drink or smoke when using this product P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish P403 + P235 - Store in a well-ventilated place. Keep cool P501 - Dispose of contents/container in accordance with local, regional, national, and international regulations as applicable Hazards not otherwise classified (HNOC) Not applicable SECTION 3: Composition/information on ingredients Single Substance or Mixture Mixture Dangerous substance or mixture according to the Globally Harmonized System (GHS). Component name CAS No % ENCS Methanol 67-56-1 14 - 25 Present SECTION 4: First aid measures General advice Immediate medical attention is required In case of accident or unwellness, seek medical advice immediately (show directions for use or safety data sheet if possible) Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. Call a physician immediately. Skin Contact Wash off immediately with plenty of water. Inhalation Immediate medical attention is required. Remove to fresh air. If not breathing, give artificial respiration. Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation. Page 2/7 Language EN Review Date 08-May-2019 277 Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. Drink plenty of water. Note to physicians Treat symptomatically. Self-protection of the first aider Remove all sources of ignition SECTION 5: Firefighting measures Flammability Flammable liquid and vapor. Suitable Extinguishing Media Dry chemical, CO2, water spray or alcohol-resistant foam. Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. Unsuitable Extinguishing Media CAUTION: All these products have a very low flash point. Use of water spray when fighting fire may be inefficient Specific hazards arising from the Vapors may form explosive mixtures with air Vapors may travel to source of ignition and chemical flash back Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks) Vapor explosion hazard indoors, outdoors or in sewers Those substances designated with a "P" may polymerize explosively when heated or involved in a fire Runoff to sewer may create fire or explosion hazard Protective equipment and As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH precautions for firefighters (approved or equivalent) and full protective gear. SECTION 6: Accidental release measures Personal precautions Remove all sources of ignition, Evacuate personnel to safe areas, Ensure adequate ventilation, especially in confined areas, Use personal protective equipment as required. Environmental precautions Prevent further leakage or spillage if safe to do so Prevent product from entering drains Do not flush into surface water or sanitary sewer system Methods for containment Prevent further leakage or spillage if safe to do so, Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry, Dike far ahead of liquid spill for later disposal. Methods for cleaning up Dam up. Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Pick up and transfer to properly labeled containers. SECTION 7: Handling and storage Precautions for safe handling Keep away from heat, sparks, flame and other sources of ignition (i.e., pilot lights, electric motors and static electricity). Keep container tightly closed. Ensure adequate ventilation, especially in confined areas. Advice on safe handling Ensure adequate ventilation, especially in confined areas. Keep away from heat, sparks, flame and other sources of ignition (i.e., pilot lights, electric motors and static electricity). Take precautionary measures against static discharges. Use spark-proof tools and explosion-proof equipment. All equipment used when handling the product must be grounded. Storage Store in accordance with local regulations. Use appropriate containment to avoid environmental contamination. SECTION 8: Exposure Controls/Personal Protection. Exposure Limits . Component name ACGIH TLV OSHA PEL NIOSH IDLH European Union Page 3/7 Language EN Review Date 08-May-2019 278 Methanol STEL: 250 ppm TWA: 200 ppm IDLH: 6000 ppm TWA: 200 ppm TWA: 260 mg/m3 TWA: 200 ppm TWA: 260 mg/m3 S* (vacated) TWA: 200 ppm TWA: 260 mg/m3 Skin (vacated) TWA: 260 mg/m3 STEL: 250 ppm (vacated) STEL: 250 ppm STEL: 325 mg/m3 (vacated) STEL: 325 mg/m3 (vacated) S* Component name China Japan Korea Australia Taiwan Hong Kong Methanol TWA: 25 mg/m3 TWA: 200 ppm Skin 200 ppm TWA: 200 ppm STEL: 50 mg/m3 TWA: 260 mg/m3 STEL: 250 ppm 262 mg/m3 TWA: 262 mg/m3 TWA: 262 mg/m3 Skin STEL: 310 mg/m3 250 ppm STEL STEL: 250 ppm ISHL/ACL: 200 TWA: 200 ppm 328 mg/m3 STEL STEL: 328 mg/m3 ppm TWA: 260 mg/m3 Skin Engineering Controls Provide adequate ventilation. Showers. Eyewash stations. Personal protective equipment (PPE) Eye/face protection Wear safety glasses with side shields (or goggles). Skin and body protection Wear protective gloves and protective clothing. Hand Protection Wear protective nitrile rubber gloves. Respiratory protection Not applicable. Other Information Environmental exposure controls No information available. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical State @20°C Liquid Appearance Colorless, Liquid Color Colorless Property Values pH 7 Melting point/freezing point 9.7 °C / -12.4 °F Boiling point / boiling range 80 °C / 177 °F Flash point 41 °C / 105 °F Method Evaporation rate 1 Flammability (solid, gas) No information available Flammability Limits in Air Upper flammability limits 36% Lower flammability limit 8.4% Vapor pressure 127 mmHg Vapor density 2.17 (Air=1) Relative density 0.97 Water solubility No information available Solubility(ies) No information available Partition coefficient No information available Autoignition temperature 500 °C / 932 °F Decomposition temperature No information available Viscosity No information available Explosive properties No information available Oxidizing properties No information available Percent Volatile >99% SECTION 10: Stability and reactivity Page 4/7 Language EN Review Date 08-May-2019 279 Stability Stable under normal conditions. Reactivity None under normal use conditions Materials to avoid Strong oxidizing agents. Acids. Metals. Incompatible materials. Strong oxidizing agents. Acids. Metals. Conditions to avoid Heat, flames and sparks. Hazardous Decomposition Products None under normal use conditions. Hazardous polymerization None under normal use conditions. Possibility of Hazardous Reactions None under normal use conditions. SECTION 11: Toxicological information Toxicological information Information on likely routes of exposure Product Information May be harmful by inhalation, ingestion, or skin absorption. Inhalation None under normal use conditions Eye contact Risk of serious damage to eyes Skin Contact None under normal use conditions Ingestion None under normal use conditions Numerical measures of toxicity - Product Information 0% of the mixture consists of ingredient(s) of unknown toxicity. The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 476.00 ATEmix (dermal) 1,429.00 ATEmix (inhalation-vapor) 14.00 Component name LD50/oral/rat - NO UNITS LD50/dermal/rat - NO UNITS Inhalation LC50 (Wizards mg/kg) Methanol = 5628 mg/kg ( Rat ) = 83.2 mg/L ( Rat ) 4 h Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation No information available. Serious eye damage/eye irritation No information available. Sensitization No information available. Germ cell mutagenicity No information available. Carcinogenicity No information available. Reproductive toxicity No information available. STOT - single exposure No information available. STOT - repeated exposure No information available. Target Organ Effects Central nervous system, Eyes, Gastrointestinal tract (GI), Respiratory system, Skin. Aspiration hazard No information available. SECTION 12: Ecological information Ecotoxicity 20 - 50% of the mixture consists of components(s) of unknown hazards to the aquatic environment. Component name Algae/aquatic plants Fish Crustacea Page 5/7 Language EN Review Date 08-May-2019 280 Sodium Chloride 12946: 96 h Lepomis macrochirus 1000: 48 h Daphnia magna mg/L mg/L LC50 static EC50 340.7 - 469.2: 48 h Daphnia magna mg/L EC50 Static Potassium Chloride 2500: 72 h Desmodesmus 1060: 96 h Lepomis macrochirus 825: 48 h Daphnia magna mg/L subspicatus mg/L EC50 mg/L LC50 static EC50 83: 48 h Daphnia magna mg/L EC50 Static Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available. Component name Partition coefficient Methanol -0.77 Other adverse effects No information available. SECTION 13: Disposal Considerations. Waste from Residues / Unused Disposal should be in accordance with applicable regional, national and local laws and Products regulations. Contaminated packaging Dispose of in accordance with federal, state and local regulations. SECTION 14: Transport information IMDG UN/ID no UN1992 Proper Shipping Name Flammable liquid, toxic, n.o.s. Hazard Class 3 Subsidiary hazard class 6.1 Packing group III EmS No. F-E, S-D Description UN1992 Flammable liquid, toxic, n.o.s. (Methanol), 3(6.1) III IATA UN/ID no UN1992 Proper Shipping Name Flammable liquid, toxic, n.o.s. Hazard Class 3 Subsidiary hazard class 6.1 Packing group III ERG Code 3P Description UN1992, Flammable liquid, toxic, n.o.s. (Methanol), 3 (6.1), III SECTION 15: Regulatory information International Inventories All of the components in the product are on the following Inventory lists . Component name