Note: Ingredients listed on restricted chemical lists
EC/CAS
9003-39-8
Name of the chemical
polyvinylpyrrolidone
Concentration
3%
EC/CAS
14807-96-6
Name of the chemical
Talc
Concentration
1%
General Information
Product name
ERIVEDGE(R) Capsules (150 mg)
Product Synonyms
- Hedgehog signaling pathway antagonist RO5450815
Icons in SDS
Company Information
company name
Hoffmann-La Roche Inc
e-mail address of the competent person responsible for the Safety Data Sheet
info.sds@roche.com
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H360D, H360F, H373
Hazard statements
Code
Statements
H360D
May damage the unborn child
Section 2
SECTION 2: Hazards identification
GHS Classification Emergency Overview Form capsules Color grey pink Hazard Overview - May cause birth defects based on animal data. - may cause reproductive system effects based on animal data
Potential health effects
Exposure: Inhalation, Ingestion, Skin contact, Eye contact - Target Organs: gastrointestinal system, Skeletal system - Acute Effects: This material has not been tested as a whole; therefore, the information described below is based on one or more of its ingredients., May cause gastrointestinal effects., Signs and symptoms may include nausea, vomiting, diarrhea, constipation, cramps, and loss of appetite., May cause musculoskeletal effects., Signs and symptoms may include muscle weakness or pain and skeletal abnormalities., May cause loss of hair., May cause general body weakness, fatigue and nausea.
Potential chronic health
No adverse effects known - Carcinogenicity not listed by NTP IARC or
Health hazards
3.7 D Reproductive toxicity (Category 1B) H360D May damage the unborn child. 3.7 F Reproductive toxicity (Category 1B) H360F May damage fertility. 3.9 Specific target organ toxicity - Repeated exposure (Category 2) H373 May cause damage to organs.
Signal word
Danger Label:
Precautionary statements
P201 Obtain special instructions before use. - P260 Do not breathe dust - P308 + P313 IF exposed or concerned: Get medical advice/attention. - P273 Avoid release to the environment. - P501 Dispose of contents/container to waste disposal as hazardous waste Additional Health Information - Reproductive Toxicity: May cause birth defects based on animal data. May affect fertility (including sperm production, ovulation, motility and impotence) based on animal data. - Since this material may affect reproductive capabilities and the developing fetus, females and males planning to have a child, pregnant women and nursing mothers should exercise caution regarding potential exposure. *2 referring to: Povidone K29/32
