TH-101 Make-up

Hazard statements (CLP)

H225, H319, H335

Code

Statements

H225

Highly Flammable liquid and vapour

CLP CLASSIFICATION

2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:]] Flammable Liquids, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Specific Target Organ Toxicity (single exposure), Category 3

2.2 Label elements

2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:

Signal word

Danger

Hazard statements

H225 - Highly flammable liquid and vapor. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation.

Precautionary statements

P233 - Keep container tightly closed. P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P240 - Ground/bond container and receiving equipment. P241 - Use explosion-proof electrical/ventilating/lighting/.../ equipment. P243 - Take precautionary measures against static discharge. P242 - Use only non-sparking tools. P264 - Wash hands thoroughly after handling. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P271 - Use only outdoors or in a well-ventilated area.

Response

P370+378 - In case of fire, use ... to extinguish. P303+361+353 - IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. P305+351+338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+313 - If eye irritation persists, get medical advice/attention. P304+340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 - Call a POISON CENTER/doctor/... if you feel unwell.

Storage

P403+235 - Store in cool/well-ventilated place. P501 - Dispose of contents/container to .... P403+233 - Store container tightly closed in well-ventilated place - if product is as volatile as to generate hazardous atmosphere. P405 - Store locked up.

Potential health effects

Prolonged or repeated skin contact may cause defatting and dermatitis. Chronic: May cause reproductive and fetal effects. Laboratory experiments have shown mutagenic effects. Animal studies have reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart damage. Chronic inhalation may cause effects similar to those of acute inhalation. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic overexposure to vapors may cause lung damage. 2.3.1 Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause narcotic effects in high concentration. Causes upper respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause central nervous system effects such as nausea and headache. Neurobehavioural effects of exposure to MEK (200 ppm for 4 hrs) were studied with 137 volunteers. There were no statistically significant effects observed in biochemical, psychomotor, sensorimotor and psychological tests. 2.3.2 Skin Contact: Causes moderate skin irritation. May cause cyanosis of the extremities. May cause irritation with pain and stinging, especially if the skin is abraded. Isopropanol has a low potential to cause allergic skin reactions; however, rare cases of allergic contact dermatitis have been reported. Dermal absorption has been considered toxicologically insignificant. The cases of deep coma associated with skin contact are thought to be a consequence of gross isopropanol vapor inhalation in rooms with inadequate ventilation, rather than being attributable to percutaneous absorption of isopropanol per se. May be absorbed through the skin in harmful amounts. Repeated or prolonged exposure may cause drying and cracking of the skin. Only one human case of skin sensitization was located. Negative results were obtained in an animal test; MEK did not produce skin sensitization in the mouse ear thickness test. 2.3.3 Eye Contact: Causes severe eye irritation. May cause painful sensitization to light. May cause chemical conjunctivitis and corneal damage. Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. May cause transient corneal injury. Causes eye irritation. Vapors may cause eye irritation. Animal evidence suggests that MEK is a moderate to severe eye irritant. 2.3.4 Ingestion: May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. The probable oral lethal dose in humans is 240 ml (2696 mg/kg), but ingestion of only 20 ml (224 mg/kg) has, but in gestion of only 20 ml (224 mg/kg) has caused poisoning. May cause irritation of the digestive tract. Possible aspiration hazard. May cause central nervous system depression. Animal evidence suggests that MEK can be aspirated (inhaled) into the lungs during ingestion or vomiting.