JP-K69

SECTION 2: Hazards identification

Flammable Liquids, Category 2 Acute Toxicity: Oral, Category 5 Acute Toxicity: Skin, Category 5 Acute Toxicity: Inhalation, Category 5 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Germ Cell Mutagenicity, Category 1B Carcinogenicity, Category 2 Toxic To Reproduction, Category 1B Specific Target Organ Toxicity (single exposure), Category 1 Specific Target Organ Toxicity (single exposure), Category 3 Specific Target Organ Toxicity (repeated exposure), Category 1 Specific Target Organ Toxicity (repeated exposure), Category 2 Aspiration Toxicity, Category 2

Signal word

Danger

Hazard statements

Highly flammable liquid and vapor. May be harmful if swallowed. May be harmful in contact with skin. May be harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause genetic defects state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard. Suspected of causing cancer state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard. May damage fertility or the unborn child . Causes damage to organs May cause respiratory irritation. Causes damage to organs through prolonged or repeated exposure. May cause damage to organs through prolonged or repeated exposure. May be harmful if swallowed and enters airways.

Precautionary statements

Keep container tightly closed. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary measures against static discharge. Use only non-sparking tools. Wash hands thoroughly after handling. Take off contaminated clothing and wash it before reuse. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapours/spray. Do not eat, drink or smoke when using this product. Avoid breathing dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area.

Response

In case of fire, use dry chemical, CO2, water splay, fog or form to extinguish. IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. Call a POISON CENTER/doctor if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. Specific treatment see section 4 on this label. If skin irritation occurs, get medical advice/attention. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical advice/attention. IF exposed or concerned: Get medical attention/advice. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention/advice if you feel unwell. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Do NOT induce vomiting.

Storage

Store in cool/well-ventilated place. Dispose of contents/container listed in 40 CFR Parts 261. Store locked up. Store container tightly closed in well-ventilated place - if product is as volatile as to generate hazardous atmosphere. Flammability Hazard Rating System: Instability HEALTH 2 3 FLAMMABILITY 3 2 0 PHYSICAL 0 Health PPE B HMIS: NFPA: Special Hazard

Potential health effects

Chronic: Chronic inhalation may cause effects similar to those of acute inhalation. (Acute and Chronic): Prolonged or repeated skin contact may cause defatting and dermatitis. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic overexposure to vapors may cause lung damage. May cause reproductive and fetal effects. Laboratory experiments have shown mutagenic effects. Animal studies have reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart damage. Chronic exposure may cause liver damage. Prolonged or repeated skin contact may cause dermatitis. Chronic exposure may cause effects similar to those of acute exposure. Methanol is only very slowly eliminated from the body. Because of this slow elimination, methanol should be regarded as a cumulative poison. Though a single exposure may cause no effect, daily exposures may result in the accumulation of a harmful amount. Methanol has produced fetotoxicity in rats and teratogenicity in mice exposed by inhalation to high concentrations that did not produce significant maternal toxicity. Possible cancer hazard based on tests with laboratory animals. May cause liver and kidney damage. Sophisticated modeling has clearly proven that 2-butoxyethanol does not build up in the body under any kinds of normal use. Inhalation: Causes respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause central nervous system effects such as nausea and headache. Neurobehavioural effects of exposure to MEK (200 ppm for 4 hrs) were studied with 137 volunteers. There were no statistically significant effects observed in biochemical, psychomotor, sensorimotor and psychological tests. Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause narcotic effects in high concentration. Vapors may cause dizziness or suffocation. Inhalation of vapor may cause respiratory tract irritation. May cause effects similar to those described for ingestion. Methanol is toxic and can very readily form extremely high vapor concentrations at room temperature. Inhalation is the most common route of occupational exposure. At first, methanol causes CNS depression with nausea, headache, vomiting, dizziness and incoordination. A time period with no obvious symptoms follows (typically 8-24 hrs). This latent period is followed by metabolic acidosis and severe visual effects which may include reduced reactivity and/or increased sensitivity to light, blurred, doubl and/or snowy vision, and blindness. Depending on the severity of exposure and the promptness of treatment, survivors may recover completely or may have permanent blindness, vision disturbances and/or nervous system effects. Dust is irritating to the respiratory tract. Exposure may impair lung function and cause mucostasis (reduced mucous clearance). Carbon black dust is extremely fine and light and can be breathed deeply into the lungs, where it can accumulate. Normally the dust is cleared gradually and has no harmful effects. However, high concentrations can overwhelm the clearance capacity of the lungs, and impair function. Harmful if inhaled. May cause respiratory tract irritation. May cause lung damage. May cause anemia. Skin Contact: May be absorbed through the skin in harmful amounts. Repeated or prolonged exposure may cause drying and cracking of the skin. Only one human case of skin sensitization was located. Negative results were obtained in an animal test; MEK did not produce skin sensitization in the mouse ear thickness test. Causes moderate skin irritation. May cause cyanosis of the extremities. May cause moderate skin irritation. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. Methanol can be absorbed through the skin, producing systemic effects that include visual disturbances. May cause skin irritation. Causes skin irritation. Harmful if absorbed through the skin. Substance is rapidly absorbed through the skin. Causes symptoms similar to those of inhalation. Skin sensitization testing with human volunteers produced negative results. A skin notation is not recommended by ACGIH, based on estimates from physiologically based pharmacokinetic models which indicate that, even in worst-case dermal-exposure scenarios, 2-butoxyethanol is not absorbed in amounts sufficient to cause red blood cell hemolysis in humans. Eye Contact: Causes eye irritation. Vapors may cause eye irritation. Animal evidence suggests that MEK is a moderate to severe eye irritant. Causes severe eye irritation. May cause painful sensitization to light. May cause chemical conjunctivitis and corneal damage. May cause moderate eye irritation. May result in corneal injury. Methanol is a mild to moderate eye irritant. Inhalation, ingestion or skin absorption of methanol can cause significant disturbances in vision, including blindness. Causes redness and pain. Ingestion: May cause irritation of the digestive tract. Possible aspiration hazard. May cause central nervous system depression. Animal evidence suggests that MEK can be aspirated (inhaled) into the lungs during ingestion or vomiting. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be fatal or cause blindness if swallowed. Aspiration hazard. Cannot be made non-poisonous. May cause cardiopulmonary system effects. Ingestion of large amounts may cause gastrointestinal irritation. Harmful if swallowed.