JP-B82 Printing Ink

Hazard statements (CLP)

H225, H301, H311, H316, H318, H331, H341, H350, H360, H370

Code

Statements

H225

Highly Flammable liquid and vapour

CLP CLASSIFICATION

2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:]] Flammable Liquids, Category 2 Skin Corrosion/Irritation, Category 3 Germ Cell Mutagenicity, Category 2 Carcinogenicity, Category 1B Toxic To Reproduction, Category 1B Specific Target Organ Toxicity (single exposure), Category 1

2.2 Label elements

2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:

Signal word

Danger

Hazard statements

H225 - Highly flammable liquid and vapor. H331 - Toxic if inhaled. H301 - Toxic if swallowed. H311 - Toxic in contact with skin. H316 - Causes mild skin irritation. H318 - Causes serious eye damage. H341 - Suspected of causing genetic defects. H350 - May cause cancer state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard. H360 - May damage fertility or the unborn child . H370 - Causes damage to organs

Precautionary statements

P233 - Keep container tightly closed. P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P240 - Ground/bond container and receiving equipment. P241 - Use explosion-proof electrical/ventilating/lighting/.../ equipment. P243 - Take precautionary measures against static discharge. P242 - Use only non-sparking tools. P271 - Use only outdoors or in a well-ventilated area. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash hands thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. P361+364 - Take off immediately all contaminated clothing and wash it before reuse. P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P281 - Use personal protective equipment as required. P260 - Do not breathe dust/fume/gas/mist/vapours/spray.

Response

P370+378 - In case of fire, use ... to extinguish. P303+361+353 - IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. P304+340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P311 - Call a POISON CENTER/doctor/.... P322 - Specific measures see ... on this label. P301+310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330 - Rinse mouth. P321 - Specific treatment see ... on this label. P302+352 - IF ON SKIN: Wash with plenty of soap and water. P312 - Call a POISON CENTER/doctor/... if you feel unwell. P332+313 - If skin irritation occurs, get medical advice/attention. P305+351+338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 - Immediately call a POISON CENTER/doctor/.... P308+313 - IF exposed or concerned: Get medical attention/advice.

Storage

P403+235 - Store in cool/well-ventilated place. P501 - Dispose of contents/container to .... P405 - Store locked up. P403+233 - Store container tightly closed in well-ventilated place - if product is as volatile as to generate hazardous atmosphere.

Potential health effects

Chronic: Chronic inhalation may cause effects similar to those of acute inhalation. Prolonged or repeated skin contact may cause defatting and dermatitis. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic overexposure to vapors may cause lung damage. Adverse reproductive effects have been reported in animals. Laboratory experiments have shown mutagenic effects. Animals exposed to 4300 ppm (mice) and 2000 ppm (guinea pig), 6 hours/day for 7 days developed minor blood changes & loss of appetite. There was no indication of liver or kidney injury. Rabbits exposed to 16000 mg/m3 (4440 ppm), 1 hour/day for 40 days developed secondary anemia (decreased number of red blood cells), decreased hemoglobin levels, increased numbers of macrophages, congestion and fatty degeneration of various organs, and enlargement of the spleen. A reviewer suggested that the organ damage may have been due to impurities present in the ethyl. Prolonged or repeated skin contact may cause dermatitis. Testicular effects in rats were noted after repeated, high-dose oral and inhalation exposures. (BASF) Human occupational exposure has been associated with chronic eye irritation, headaches, and irritant contact dermatitis. Airborne concentrations of 49 to 83 ppm are intolerable. (REPROTEXT) 2.3.1 Inhalation: Causes respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause central nervous system effects such as nausea and headache. Neurobehavioural effects of exposure to MEK (200 ppm for 4 hrs) were studied with 137 volunteers. There were no statistically significant effects observed in biochemical, psychomotor, sensorimotor and psychological tests. May cause respiratory tract irritation. May be harmful if inhaled. Inhalation of high concentrations may cause narcotic effects. May cause headache. Material has a very low vapor pressure at room temperature, so inhalation exposures are not expected unless material is heated or misted. The toxicological properties of this substance have not been fully investigated. 2.3.2 Skin Contact: May be absorbed through the skin in harmful amounts. Repeated or prolonged exposure may cause drying and cracking of the skin. Only one human case of skin sensitization was located. Negative results were obtained in an animal test; MEK did not produce skin sensitization in the mouse ear thickness test. Causes mild skin irritation. May be harmful if absorbed through the skin. May cause skin irritation. The majority of human studies have demonstrated that ethyl acetate does not cause an allergic response on human skin. However, there is one case report of a woman developing a skin allergy to ethyl acetate. Causes skin irritation. Not expected to cause an allergic skin reaction. Because of the high permeability rate of N-methylpyrrolidone in human skin, prolonged exposures should be avoided. 2.3.3 Eye Contact: Causes eye irritation. Vapors may cause eye irritation. Animal evidence suggests that MEK is a moderate to severe eye irritant. Causes mild eye irritation. May cause temporary corneal clouding. May cause chemical conjunctivitis and corneal damage. 2.3.4 Ingestion: May cause irritation of the digestive tract. Possible aspiration hazard. May cause central nervous system depression. Animal evidence suggests that MEK can be aspirated (inhaled) into the lungs during ingestion or vomiting. May be harmful if swallowed. Ingestion of large amounts may cause central nervous system depression. May cause headache, nausea, fatigue, and dizziness. These effects may be caused in part by ethanol which is released when ethyl acetate is broken down in the body. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.