General Information
Version
3.1.1.1
Revision date
2016-04-07
Product name
BORTEZOMIB
Product Synonyms
cytotoxic, butyl] boronic acid, protease inhibitor, pyrazinoic acid, phenylalanine, leucine, boric acid, tripeptide proteasome inhibitor
Chemical name
C19-H25-B-N4-O4, PS-341, Pyz-Phe-borLeu, Velcade, [(1R)-3-methyl-1-({(2S-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)-, antineoplastic/ cytotoxic, butyl] boronic acid, protease inhibitor, pyrazinoic acid, phenylalanine, leucine, boric acid, tripeptide proteasome inhibitor
CAS No.
179324-69-7
1.2.1 Relevant identified uses
with high affinity and specificity. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitinylated proteins, and also cleanses the cell of abnormal or misfolded proteins. Clinical and preclinical data support a role in maintaining the immortal phenotype of myeloma cells, and cell-culture and xenograft data support a similar function in solid tumor cancers. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent degradation of pro...
Icons in SDS
Company Information
company name
Hetero Labs Ltd
GHS Information
Signal word
WARNING
Hazard Codes
Hazard statements (CLP)
H361
Hazard statements
Code
Statements
H361
Suspected of damaging fertility or the unborn child
Section 2
SECTION 2: Hazards identification
Classification of the substance or mixture CHEMWATCH HAZARD RATINGS Min Max
Signal word
WARNING Hazard statement(s) H361 Suspected of damaging fertility or the unborn child Precautionary statement(s) Prevention P201 Obtain special instructions before use P280 Wear protective gloves/protective clothing/eye protection/face protection Precautionary statement(s) Response P308+P313 IF exposed or concerned: Get medical advice/ attention Precautionary statement(s) Storage P405 Store locked up
Disposal
P501 Dispose of contents/container in accordance with local regulations.
2.1 Classification of the substance or mixture
CHEMWATCH HAZARD RATINGS Min Max NFPA 704 diamond Flammability 1 Toxicity 1 Body Contact 0 Reactivity 1 0 = Minimum 1 = Low Chronic 2 2 = Moderate Note: The hazard category numbers found in GHS classification in section 2 of this 3 = High SDSs are NOT to be used to fill in the NFPA 704 diamond. Blue = Health Red = 4 = Extreme Fire Yellow = Reactivity White = Special (Oxidizer or water reactive substances) CANADIAN WHMIS SYMBOLS Classification Reproductive Toxicity Category 2
