Levofloxacin hemihydrate

SECTION 2: Hazards identification

Usual adult dose: The usual oral adult dose of ofloxacin is 200 to 400 mg every 12 hours. Adverse effects: Adverse effects may include nausea, diarrhea, vomiting, mild abdominal or stomach pain, dizziness, headache, nervousness, drowsiness or insomnia, increased sensitivity of skin to sunlight, vaginitis, skin problems, and taste disturbances. Possible allergic reaction to material if inhaled, ingested or in contact with skin. Overdose effects: There is limited information regarding overdose with ofloxacin, but symptoms may include drowsiness, nausea, dizziness, hot and cold flushed, facial swelling and numbness, slurred speech, and moderate disorientation. Acute: Possible eye, skin, gastrointestinal and/or respiratory tract irritation. - 1 - Chronic: Possible hypersensitization Inhalation: May cause irritation. Remove to fresh air. Eye: May cause irritation. Flush with copious quantities of water. Skin: May cause irritation. Flush with copious quantities of water. Ingestion: May cause irritation. Flush out mouth with water. This material is rapidly and well absorbed from the gastrointestinal tract.

Medical Conditions Generally Aggravated by Exposure

Hypersensitivity to the material, CNS disorders including cerebral arteriosclerosis, epilepsy or other predisposition to seizures, history of photosensitivity, impaired kidney function, and history of tendonitis or tendon rupture. Cross sensitivity: Persons sensitive to fluoroquinolones or other chemically related quinolone derivatives may be sensitive to this material also. Pregnancy comments: Adequate and well-controlled pregnancy studies in humans have not been done. Although studies in rats and rabbits given large doses have not shown that ofloxacin causes birth defects, other quinolones have been known to cause joint disease in immature animals.