Kuraray Poval

SECTION 2: Hazards identification

Expected route of entry: Skin contact : Yes Skin absorption : Yes Eye contact : Yes Inhalation : Yes Ingestion : Yes Effects of exposure: Methanol Poisoning is usually caused by ingestion. Poisoning by inhalation of vapor is uncommon but can occur at extreme levels of exposure. Intoxication by skin absorption is unlikely unless prolonged contact occurs with injured skin. Acute systemic toxicity is manifested in acidosis and injury to the optic nerve. Onset of symptoms may be delayed as long as 30 hours. A latent period of 12-18 hours is common. Mild intoxication may be associated with non-specific headache, fatigue, nausea and blurring of vision, usually reversible. Moderate intoxication may produce severe headache, dizziness, nausea, vomiting, abdominal or lumbar pain and depression of the central nervous system. Blurring or loss of vision may be temporary to permanent and generally follows latent periods of two to six days. In severe intoxication, these findings are accentuated and there may be shock, coma and hyperemia of the optic disc with blurring of the disc margins. Acidosis is a prominent observation. Death has been reported in about 25% of patients with severe poisoning (carbon dioxide combining power less than 20 meg/l). Visual disturbances, the most damaging aspect of most cases of intoxication, may develop promptly with little warning. The loss of acuity may be accompanied by the perception of spots or a grey mist. Changes in color perception, scotomatia, photophobia or tenderness of the eyes. Prognosis for improvement of vision is poor if changes persist for 6 days. Chronic poisoning from inhalation has been described as showing visual impairment with blurring, loss of acuity, contraction of fields and sometimes total blindness. This condition is believed to be exceedingly rare and not well documented. Liquid and vapor may be irritating to the skin and mucous membranes. May have a defatting action upon the skin and dryness and vulnerability to infection may result. Known effects on other illnesses: Persons with pre-existing eye or skin disorders or impaired pulmonary function may be more susceptible to the effects of this product. Listed carcinogen: