Polymyxin B for Injection, USP

Signal word

WARNING. GHS Class: Acute Inhalation Toxicity. Category 4. Acute Oral Toxicity. Category 4.

Hazard statements

Harmful if inhaled. Harmful if swallowed.

Precautionary statements

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with Local, State, Federal and Provincial regulations. Emergency Overview: This product is intended for therapeutic use only when prescribed by a physician. Potential adverse reactions from prescribed doses and overdoses are described in the package insert.

Principle Routes of Exposure

Inhalation Ingestion Eye contact Skin Absorption. Injection.

Potential health effects

Signs/Symptoms: Potential adverse reactions from prescribed doses and overdoses are described in the package insert. Side effects from therapeutic doses include: fever, urticarial rash, pain (severe) at intramuscular injection sites, and thrombophlebitis at intravenous injection sites. Target Organs: Kidney and nervous system, based on clinical use as described in the Physicians Desk Reference. Aggravation of Pre-Existing Individuals with a prior history of hypersensitivity reactions to polymyxins, impaired renal function, and Conditions: concurrent use of other nephrotoxic drugs particularly bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, and colistin.