Topotecan Hydrochloride for Injection, USP

Hazard statements (CLP)

H362

Code

Statements

H362

May cause harm to breast-fed children

SECTION 2: Hazards identification

GHS Class Reproductive toxicity. Effects on or via lactation.

Hazard statements

May cause harm to breast-fed children.

Precautionary statements

Obtain special instructions before use. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid contact during pregnancy and while nursing. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this product. IF exposed or concerned: Get medical advice/attention. Emergency Overview This product is intended for therapeutic use only when prescribed by a physician. Potential adverse reactions from prescribed doses and overdoses are described in the package insert. Avoid contact with skin, eyes, nostrils and mouth.

Principle Routes of Exposure

Inhalation Ingestion Eye contact Skin Absorption. Injection.

Potential health effects

Caution - Potent pharmaceutical agent. May cause cancer. May produce adverse effects on the development of human offspring. Possible effects of overexposure in the workplace include: nausea; vomiting; diarrhoea; bone marrow toxicity. Eye Contact with eyes may cause irritation. Skin May cause irritation. Inhalation May cause irritation. Ingestion May be harmful if ingested. Signs/Symptoms Overexposure in the workplace might have the following effects: reduced white blood cell count; nausea; diarrhoea; vomiting; fatigue. Target Organs bone marrow and formation of blood cells Aggravation of Pre-Existing None generally recognized. Conditions