Crizotinib

Hazard statements (CLP)

H317, H319, H341, H400

Code

Statements

H317

May cause an allergic skin reaction

SECTION 2: Hazards identification

Classification of the substance or mixture Classification H317 Skin Sens. 1 H319 Eye Irrit. 2 H341 Muta. 2 H400 Aquatic Acute 1

Signal word

Warning

Hazard pictograms

GHS07 GHS08 GHS09 H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H341 Suspected of causing genetic defects. H400 Very toxic to aquatic life.

Precautionary statements

P101 If medical advice is needed, have product container or label at hand. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash hands thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing and eye/face protec- tion. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P302+P352 IF ON SKIN: Wash with plenty of water and soap. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all con- taminated clothing. Rinse skin with water. P304+P340 IF INHALED: Remove person to fresh air and keep com- fortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for sev- eral minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P321 Specific treatment (see Section 4 on this SDS). P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P391 Collect spillage. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container to hazardous waste disposal.

Supplemental label elements

None

2.3 Other hazards

Other Classification Hazards This substance/mixture contains no components consid- ered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

ECOLOGICAL INFORMATION

This substance/mixture contains no components consid- ered to have endocrine disrupting properties for environ- ment , according to REACH Article 57(f), Commission Regulation (EU) 2018/605 or Commission Delegated Regulation (EU) 2017/2100.

TOXICOLOGICAL INFORMATION

This substance/mixture contains no components consid- ered to have endocrine disrupting properties affecting hu- man health, according to REACH Article 57(f), Commission Regulation (EU) 2018/605 or Commission Delegated Regulation (EU) 2017/2100.

2.1 Classification of the substance or mixture

Classification H317 Skin Sens. 1 H319 Eye Irrit. 2 H341 Muta. 2 H400 Aquatic Acute 1